日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell Growth

抑制癌相关成纤维细胞中的ACVR1可抑制结直肠癌细胞生长

Shinya Kato ,Norikatsu Miyoshi ,Shiki Fujino ,Masafumi Horie ,Shinichi Yachida ,Mitsunobu Takeda ,Yuki Sekido ,Tsuyoshi Hata ,Atsushi Hamabe ,Takayuki Ogino ,Mamoru Uemura ,Hirofumi Yamamoto ,Masayoshi Yasui ,Masayuki Ohue ,Yuichiro Doki ,Hidetoshi Eguchi

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

将凡德他尼联合依维莫司用于治疗ACVR1突变型弥漫性内生性脑桥胶质瘤

Diana M Carvalho ,Peter J Richardson ,Nagore Olaciregui ,Reda Stankunaite ,Cinzia Lavarino ,Valeria Molinari ,Elizabeth A Corley ,Daniel P Smith ,Ruth Ruddle ,Adam Donovan ,Akos Pal ,Florence I Raynaud ,Sara Temelso ,Alan Mackay ,John P Overington ,Anne Phelan ,David Sheppard ,Andrew Mackinnon ,Bassel Zebian ,Safa Al-Sarraj ,Ashirwad Merve ,Jeremy Pryce ,Jacques Grill ,Michael Hubank ,Ofelia Cruz ,Andres Morales La Madrid ,Sabine Mueller ,Angel M Carcaboso ,Fernando Carceller ,Chris Jones

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

抗ACVR1抗体可加剧进行性骨化性纤维发育不良小鼠体内纤维脂肪祖细胞的异位骨化。

John B Lees-Shepard ,Sean J Stoessel ,Julian T Chandler ,Keith Bouchard ,Patricia Bento ,Lorraine N Apuzzo ,Parvathi M Devarakonda ,Jeffrey W Hunter ,David J Goldhamer

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

突变型ACVR1抑制神经胶质细胞分化,从而驱动儿童胶质瘤的发生

Jerome Fortin ,Ruxiao Tian ,Ida Zarrabi ,Graham Hill ,Eleanor Williams ,Gonzalo Sanchez-Duffhues ,Midory Thorikay ,Parameswaran Ramachandran ,Robert Siddaway ,Jong Fu Wong ,Annette Wu ,Lorraine N Apuzzo ,Jillian Haight ,Annick You-Ten ,Bryan E Snow ,Andrew Wakeham ,David J Goldhamer ,Daniel Schramek ,Alex N Bullock ,Peter Ten Dijke ,Cynthia Hawkins ,Tak W Mak

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification

NF-κB/MAPK激活是ACVR1介导的人类异位骨化炎症的基础

Emilie Barruet ,Blanca M Morales ,Corey J Cain ,Amy N Ton ,Kelly L Wentworth ,Tea V Chan ,Tania A Moody ,Mariëlle C Haks ,Tom Hm Ottenhoff ,Judith Hellman ,Mary C Nakamura ,Edward C Hsiao

Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva

肥大细胞和巨噬细胞的耗竭会损害进行性骨化性纤维发育不良Acvr1R206H小鼠模型中的异位骨化

Michael R Convente ,Salin A Chakkalakal ,EnJun Yang ,Robert J Caron ,Deyu Zhang ,Taku Kambayashi ,Frederick S Kaplan ,Eileen M Shore

BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints

由组成型活性激活素1型受体(ACVR1)介导的BMP信号传导导致异位骨形成,该异位骨形成局限于肢体远端关节。

Shailesh Agarwal ,Shawn J Loder ,Cameron Brownley ,Oluwatobi Eboda ,Jonathan R Peterson ,Satoru Hayano ,Bingrou Wu ,Bin Zhao ,Vesa Kaartinen ,Victor C Wong ,Yuji Mishina ,Benjamin Levi