日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

TYK2促进结直肠癌肝转移的免疫监视

Bernadette Mödl ,Daniela Zwolanek ,Katharina Schwertner ,Dana Krauß ,Stefan Moritsch ,Irene Scharf ,Anne-Sophie Ebner ,Veronica Moreno-Viedma ,Cristiano de Sa Fernandes ,Philipp Novoszel ,Martin Holcmann ,Martina Hammer ,Nunzia Matrone ,Michaela Schlederer ,Birgit Strobl ,Emilio Casanova ,Caroline Lassnig ,Dietmar Herndler-Brandstetter ,Lukas Kenner ,Mathias Müller ,Maria Sibilia ,Robert Eferl

TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation

TYK2抑制可增强Treg细胞的分化和功能,同时抑制Th1和Th17细胞的分化。

Karoliina Tuomela ,Rosa V Garcia ,Dominic A Boardman ,Pedram Tavakoli ,Maria Ancheta-Schmit ,Ho Pan Sham ,Lihong Cheng ,Mary Struthers ,Brian Bressler ,Bruce A Vallance ,Qihong Zhao ,Megan K Levings

Topical TYK2 inhibitor ameliorates psoriasis-like dermatitis via the AKT-SP1-NGFR-AP1 pathway in keratinocytes

局部应用TYK2抑制剂可通过AKT-SP1-NGFR-AP1通路改善角质形成细胞中的银屑病样皮炎

Zhiqin Fang ,Rundong Jiang ,Yutong Wang ,Wangqing Chen ,Xiang Chen ,Mingzhu Yin

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions

在稳态和应激条件下,小鼠免疫细胞对TYK2的细胞类型特异性需求

Anzhelika Karjalainen ,Agnieszka Witalisz-Siepracka ,Michaela Prchal-Murphy ,David Martin ,Felix Sternberg ,Milica Krunic ,Marlies Dolezal ,Nikolaus Fortelny ,Matthias Farlik ,Sabine Macho-Maschler ,Caroline Lassnig ,Katrin Meissl ,Lena Amenitsch ,Therese Lederer ,Elena Pohl ,Dagmar Gotthardt ,Christoph Bock ,Thomas Decker ,Birgit Strobl ,Mathias Müller

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

TYK2 在 tau 蛋白病小鼠模型中调节 tau 蛋白水平、磷酸化和聚集。

Jiyoen Kim ,Bakhos Tadros ,Yan Hong Liang ,Youngdoo Kim ,Cristian Lasagna-Reeves ,Jun Young Sonn ,Dah-Eun Chloe Chung ,Bradley Hyman ,David M Holtzman ,Huda Yahya Zoghbi

Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection

TYK2信号传导缺失增强宿主对白色念珠菌皮肤感染的抵抗力

Sara Miranda ,Caroline Lassnig ,Kristina Schmidhofer ,Hrönn Kjartansdottir ,Claus Vogl ,Simone Tangermann ,Irina Tsymala ,Verena Babl ,Mathias Müller ,Karl Kuchler ,Birgit Strobl

A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways

一种新型高选择性酪氨酸激酶2 (TYK2) 变构抑制剂可以阻断炎症和自身免疫相关通路

Celia X-J Chen # ,Wei Zhang # ,Shulan Qu ,Fucan Xia ,Yidong Zhu ,Bo Chen

Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2

人类疱疹病毒8干扰素调节因子1与STAT3和Janus激酶TYK2的直接且具有生物学意义的相互作用

Zunlin Yang ,Qiwang Xiang ,John Nicholas

Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis

抑郁症通过 AVP-AHI1-Tyk2 轴损害抗病毒先天免疫力。

Hong-Guang Zhang # ,Bin Wang # ,Yong Yang ,Xuan Liu ,Junjie Wang ,Ning Xin ,Shifeng Li ,Ying Miao ,Qiuyu Wu ,Tingting Guo ,Yukang Yuan ,Yibo Zuo ,Xiangjie Chen ,Tengfei Ren ,Chunsheng Dong ,Jun Wang ,Hang Ruan ,Miao Sun ,Xingshun Xu ,Hui Zheng

Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency

遗传性TYK2缺陷患者的结核分枝杆菌感染是由IL-23依赖性IFN-γ诱导受损引起的。

Masato Ogishi # ,Andrés Augusto Arias # ,Rui Yang # ,Ji Eun Han # ,Peng Zhang ,Darawan Rinchai ,Joshua Halpern ,Jeanette Mulwa ,Narelle Keating ,Maya Chrabieh ,Candice Lainé ,Yoann Seeleuthner ,Noé Ramírez-Alejo ,Nioosha Nekooie-Marnany ,Andrea Guennoun ,Ingrid Muller-Fleckenstein ,Bernhard Fleckenstein ,Sara S Kilic ,Yoshiyuki Minegishi ,Stephan Ehl ,Petra Kaiser-Labusch ,Yasemin Kendir-Demirkol ,Flore Rozenberg ,Abderrahmane Errami ,Shen-Ying Zhang ,Qian Zhang ,Jonathan Bohlen ,Quentin Philippot ,Anne Puel ,Emmanuelle Jouanguy ,Zahra Pourmoghaddas # ,Shahrzad Bakhtiar # ,Andre M Willasch # ,Gerd Horneff # ,Genevieve Llanora # ,Lynette P Shek # ,Louis Y A Chai # ,Sen Hee Tay # ,Hamid H Rahimi # ,Seyed Alireza Mahdaviani # ,Serdar Nepesov # ,Aziz A Bousfiha # ,Emine Hafize Erdeniz # ,Adem Karbuz # ,Nico Marr # ,Carmen Navarrete # ,Mehdi Adeli # ,Lennart Hammarstrom # ,Hassan Abolhassani # ,Nima Parvaneh # ,Saleh Al Muhsen # ,Mohammed F Alosaimi # ,Fahad Alsohime # ,Maryam Nourizadeh # ,Mostafa Moin # ,Rand Arnaout # ,Saad Alshareef # ,Jamila El-Baghdadi # ,Ferah Genel # ,Roya Sherkat # ,Ayça Kiykim # ,Esra Yücel # ,Sevgi Keles # ,Jacinta Bustamante # ,Laurent Abel # ,Jean-Laurent Casanova # ,Stéphanie Boisson-Dupuis #