CCN1相关文献与解析，生知库 | 链接生命科学的每一步

Sancho, Laura; Boisvert, Matthew M; Eddy, Trinity; Burgado, Jillybeth; Contreras, Minerva; Labarta-Bajo, Lara; Wang, Ellen; Tatsumi, Lisa; Allen, Nicola J

细胞生物学

CCN1

胶质细胞

神经科学

发表日期：2026

文献求助收藏

Circulating cellular communication network factor 1 (CCN1) as a liquid biopsy marker indicating progression in advanced melanoma

循环细胞通讯网络因子1 (CCN1) 作为液体活检标志物，可指示晚期黑色素瘤的进展

期刊:Journal of Translational Medicine

影响因子:7.5

doi:10.1186/s12967-026-07724-y

Heidrich, Isabel; Reese, Kim-Lea; Ullemeyer, Helen; Kött, Julian; Freiberg, Hanna; Geidel, Glenn; Rünger, Alessandra; Hansen-Abeck, Inga; Abeck, Finn; Schneider, Stefan W; Gebhardt, Christoffer; Pantel, Klaus; Smit, Daniel J

CCN1 drives asthmatic airway remodeling through amplification of TGF-Î²1/Smad3 signaling.

CCN1 通过放大 TGF-β1/Smad3 信号传导来驱动哮喘气道重塑。

期刊:Respiratory Research

影响因子:5

doi:10.1186/s12931-026-03506-8

Wang Ying, Xu Changjuan, Zeng Rong, Liu Xiaofei, Zhang Jintao, Pan Yun, Qi Qian, Qiao Chenxiao, Shi Shuochuan, Wang Pengfei, Liu Xuemin, Gao Mingxia, Gao Tingting, Dong Liang

Diminazene Aceturate Ameliorates Hypertension-Induced Cognitive Impairment by Disrupting the CCN1-Integrin Î±vÎ²6-TGF-Î² Axis and Preserving Mitochondrial Integrity.

二甲脒乙酸盐通过破坏 CCN1-整合素 αvβ6-TGF-β 轴并保持线粒体完整性来改善高血压引起的认知障碍。

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.202503973R

Huo Xufang, Wu Zhenyu, Zhou Xinqian, Zhou Yuancheng, Liu Jiming, Li Hongbing, Wu Yijiu, Huang You, Feng Guangling, Hu Xiaolin, Zeng Qingfan

Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy.

DDI2 的缺失通过 CCN1 驱动的补偿性自噬重塑蛋白质稳态。

期刊:iScience

影响因子:4.1

doi:10.1016/j.isci.2026.115056

Hosseini Nayyerehalsadat, Elshazly Ahmed M, Byers Holly A, Ward Madison A, Brooks Amy N, Vangala Janakiram R, Radhakrishnan Senthil K

Computational analysis of CCN1 as a druggable target predicts interactions with bioactive compounds

对CCN1作为药物靶点的计算分析预测了其与生物活性化合物的相互作用

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-34139-4

Bou Francis, Roudy; Kerek, Racha; Rima, Mohamad

CCN1

发表日期：2026

文献求助收藏

CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer.

CCN1 通过胶原介导的趋化因子分泌增强胰腺癌的肿瘤免疫抑制作用

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202500589

Fan Hongjie, Zhao Huzi, Gao Lili, Dong Yucheng, Zhang Pei, Yu Pengfei, Ji Yunfei, Chen Zhe-Sheng, Liang Xinmiao, Chen Yang

Tubule-derived CCN1 drives renal repair via Î±(v)Î²(5)-STAT6-ARG1-dependent reprogramming of macrophages.

肾小管衍生的 CCN1 通过 Î±(v)Î²(5)-STAT6-ARG1 依赖的巨噬细胞重编程驱动肾脏修复。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08340-2

CCN1 is a therapeutic target upregulated in EML4-ALK mutant lung adenocarcinoma reversibly resistant to alectinib

CCN1是EML4-ALK突变型肺腺癌中可逆性耐药的治疗靶点。

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-025-07601-4

Yihua Huang #,Jie Huang #,Jianhua Zhan #,Maojian Chen #,Jiani Zheng,Junyi He,Wenfeng Fang,Li Zhang,Jing Li

Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism

肝脏Lamp2a缺陷通过影响胆汁酸代谢促进小鼠自身免疫性胆管炎的炎症反应。

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2025.111804

Qingling Fan ，Guanya Guo ，Yinan Hu ，Yi Lu ，Rui Su ，Jiaqi Yang ，Erzhuo Xia ，Shuoyi Ma ，Miao Zhang ，Jingbo Wang ，Ting Li ，Ying Han

Astrocyte CCN1 stabilizes neural circuits in the adult brain

星形胶质细胞CCN1稳定成年大脑中的神经回路

Circulating cellular communication network factor 1 (CCN1) as a liquid biopsy marker indicating progression in advanced melanoma

循环细胞通讯网络因子1 (CCN1) 作为液体活检标志物，可指示晚期黑色素瘤的进展

CCN1 drives asthmatic airway remodeling through amplification of TGF-Î²1/Smad3 signaling.

CCN1 通过放大 TGF-β1/Smad3 信号传导来驱动哮喘气道重塑。

Diminazene Aceturate Ameliorates Hypertension-Induced Cognitive Impairment by Disrupting the CCN1-Integrin Î±vÎ²6-TGF-Î² Axis and Preserving Mitochondrial Integrity.

二甲脒乙酸盐通过破坏 CCN1-整合素 αvβ6-TGF-β 轴并保持线粒体完整性来改善高血压引起的认知障碍。

Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy.

DDI2 的缺失通过 CCN1 驱动的补偿性自噬重塑蛋白质稳态。

Computational analysis of CCN1 as a druggable target predicts interactions with bioactive compounds

对CCN1作为药物靶点的计算分析预测了其与生物活性化合物的相互作用

CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer.

CCN1 通过胶原介导的趋化因子分泌增强胰腺癌的肿瘤免疫抑制作用

Tubule-derived CCN1 drives renal repair via Î±(v)Î²(5)-STAT6-ARG1-dependent reprogramming of macrophages.

肾小管衍生的 CCN1 通过 Î±(v)Î²(5)-STAT6-ARG1 依赖的巨噬细胞重编程驱动肾脏修复。

CCN1 is a therapeutic target upregulated in EML4-ALK mutant lung adenocarcinoma reversibly resistant to alectinib

CCN1是EML4-ALK突变型肺腺癌中可逆性耐药的治疗靶点。

Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism

肝脏Lamp2a缺陷通过影响胆汁酸代谢促进小鼠自身免疫性胆管炎的炎症反应。