日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2- breast cancer

羟氯喹增强哌柏西利和来曲唑对 ER+/HER2- 乳腺癌疗效的 I 期试验

Akshara Singareeka Raghavendra, Nicole M Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S Gombos, Kelly K Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

Ezrin 通过 EGFR-AKT 信号传导定义内体区室中的 TSC 复合物激活

Giuliana Giamundo #, Daniela Intartaglia #, Eugenio Del Prete, Elena Polishchuk, Fabrizio Andreone, Marzia Ognibene, Sara Buonocore, Bruno Hay Mele, Francesco Giuseppe Salierno, Jlenia Monfregola, Dario Antonini, Paolo Grumati, Alessandra Eva, Rossella De Cegli, Ivan Conte

Chelerythrine triggers the prolongation of QT interval and induces cardiotoxicity by promoting the degradation of hERG channels

白屈菜红碱通过促进 hERG 通道的降解,引发 QT 间期延长并诱发心脏毒性

Fang Wang, Baoqiang Wang, Xiwei Gu, Xiaoxu Li, Xinyu Liu, Baoxin Li

Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron

Bafilomycin A1 通过破坏依赖铁的内溶酶体系统诱导结肠癌细胞死亡

Dong Hwa Min, Dasom Kim, Seung Taek Hong, Joohee Kim, Min Jung Kim, Seung-Hae Kwon, Aeree Kim, Ji-Yun Lee

Oral trehalose improves histological and behavior symptoms of mucopolysaccharidosis type II in iduronate 2-sulfatase deficient mice

口服海藻糖可改善艾杜糖醛酸 2-硫酸酯酶缺乏小鼠 II 型粘多糖贮积症的组织学和行为症状

Hyesook Lee #, Jung-Hwa Han #, Roo Gam Jeong, Yun Jeong Kang, Byung Hyun Choi, Seo Rin Kim, Chong Kun Cheon, Jin Hur, Soo Yong Lee0

Repeated CD107a Staining Enables Identification of Serial Degranulating NK Cells

重复CD107a染色可识别连续脱颗粒的NK细胞

Niemann, Jens; Claus, Maren; Imširović, Vanna; Watzl, Carsten

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease

稳态小胶质细胞最初形成种子,而活化的小胶质细胞随后重塑阿尔茨海默病中的淀粉样斑块。

Nóra Baligács ,Giulia Albertini ,Sarah C Borrie ,Lutgarde Serneels ,Clare Pridans ,Sriram Balusu ,Bart De Strooper

Deficiency of galactosyl-ceramidase in adult oligodendrocytes worsens disease severity during chronic experimental allergic encephalomyelitis

成人少突胶质细胞中半乳糖神经酰胺酶的缺乏使慢性实验性过敏性脑脊髓炎期间的病情严重程度恶化

Natalia Saldivia, Gregory Heller, Diego Zelada, Jason Whitehair, Nikhil Venkat, Ashna Konjeti, Reina Savitzky, Shayla Samano, Daniel Simchuk, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone

Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA

抗淀粉样蛋白治疗对神经病性粘多糖病具有广泛疗效,并与 MPS-IIIA 的基因治疗产生协同作用

Marianna Giaccio, Antonio Monaco, Laura Galiano, Andrea Parente, Luigi Borzacchiello, Riccardo Rubino, Frank-Gerrit Klärner, Dennis Killa, Claudia Perna, Pasquale Piccolo, Marcello Marotta, Xuefang Pan, Marie Khijniak, Ibrar Siddique, Thomas Schrader, Alexey V Pshezhetsky, Nicolina Cristina Sorrenti

Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging

哺乳动物大脑的纵向自噬分析揭示了在健康衰老过程中持续的线粒体自噬

Anna Rappe, Helena A Vihinen, Fumi Suomi, Antti J Hassinen, Homa Ehsan, Eija S Jokitalo, Thomas G McWilliams