日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

磷酸酶PTPN22在mTORC2复合物中发挥接头蛋白的作用。

Keshav Gupta ,Nagalakshmi Kommineni ,Tanuja Bogadi ,Neeraja P Alamuru-Yellapragada ,Subbareddy Maddika

Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression

雄激素通过T细胞内在的Ptpn22磷酸酶表达调控,导致小鼠自身免疫性疾病的性别偏倚。

Jean Lee ,Leonid A Yurkovetskiy ,Derek Reiman ,Lara Frommer ,Zoe Strong ,Anthony Chang ,George J Kahaly ,Aly A Khan ,Alexander V Chervonsky

Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy

树突状细胞固有蛋白PTPN22负向调控抗肿瘤免疫,并影响抗PD-L1疗效。

Santiago Acero-Bedoya ,Emily F Higgs ,Anna C Martinez ,Ruxandra Tonea ,Thomas F Gajewski

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

T细胞中PTPN22 R620W基因编辑增强低亲和力TCR反应

Warren Anderson ,Fariba Barahmand-Pour-Whitman ,Peter S Linsley ,Karen Cerosaletti ,Jane H Buckner ,David J Rawlings

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

SH3结构域突变选择性地破坏Csk同源二聚化或PTPN22结合

Ben F Brian 4th ,Frances V Sjaastad ,Tanya S Freedman

Systemic inhibition of PTPN22 augments anticancer immunity

系统性抑制PTPN22可增强抗癌免疫力

Won Jin Ho ,Sarah Croessmann ,Jianping Lin ,Zaw H Phyo ,Soren Charmsaz ,Ludmila Danilova ,Aditya A Mohan ,Nicole E Gross ,Fangluo Chen ,Jiajun Dong ,Devesh Aggarwal ,Yunpeng Bai ,Janey Wang ,Jing He ,James M Leatherman ,Mark Yarchoan ,Todd D Armstrong ,Neeha Zaidi ,Elana J Fertig ,Joshua C Denny ,Ben H Park ,Zhong-Yin Zhang ,Elizabeth M Jaffee

Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis

利用PTPN22基因特征预测类风湿性关节炎对靶向治疗的反应

Hui-Hsin Chang ,Ching-Huang Ho ,Beverly Tomita ,Andrea A Silva ,Jeffrey A Sparks ,Elizabeth W Karlson ,Deepak A Rao ,Yvonne C Lee ,I-Cheng Ho

Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22

IL-10 缺陷小鼠的实验性结肠炎在缺乏 PTPN22 的情况下会得到缓解

T Jofra ,G Galvani ,I Cosorich ,L De Giorgi ,A Annoni ,A Vecchione ,C Sorini ,M Falcone ,G Fousteri

Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22

缺乏 PTPN22 的 CD8+ T 细胞对 TGFβ 抑制具有抵抗力,且抗肿瘤反应增强

Rebecca J Brownlie ,Celine Garcia ,Mate Ravasz ,Dietmar Zehn ,Robert J Salmond ,Rose Zamoyska

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

NLRP3酪氨酸磷酸化受蛋白酪氨酸磷酸酶PTPN22的调控。

Marianne R Spalinger, Stephanie Kasper, Claudia Gottier, Silvia Lang, Kirstin Atrott, Stephan R Vavricka, Sylvie Scharl, Tina Raselli, Isabelle Frey-Wagner, Petrus M Gutte, Markus G Grütter, Hans-Dietmar Beer, Emmanuel Contassot, Andrew C Chan, Xuezhi Dai, David J Rawlings, Florian Mair, Burkhard Becher, Werner Falk, Michael Fried, Gerhard Rogler, Michael Scharl