日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer

一项针对STK11缺陷型非小细胞肺癌的mTORC1/2抑制剂II期临床试验

Gary Middleton # ,Helen L Robbins # ,Peter Fletcher ,Joshua Savage ,Manita Mehmi ,Yvonne Summers ,Alastair Greystoke ,Nicola Steele ,Sanjay Popat ,Pooja Jain ,James Spicer ,Judith Cave ,Paul Shaw ,David Gilligan ,Danielle Power ,Dean Fennell ,Maya Bajracharya ,David J McBride ,Uma Maheswari ,Alexander M Frankell ,Charles Swanton ,Andrew D Beggs ,Lucinda Billingham

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

STK19促进转录偶联DNA修复过程中受损停滞的RNAPII的清除

Diana van den Heuvel,Marta Rodríguez-Martínez,Paula J van der Meer,Nicolas Nieto Moreno,Jiyoung Park,Hyun-Suk Kim,Janne J M van Schie,Annelotte P Wondergem,Areetha D'Souza,George Yakoub,Anna E Herlihy,Krushanka Kashyap,Thierry Boissière,Jane Walker,Richard Mitter,Katja Apelt,Klaas de Lint,Idil Kirdök,Mats Ljungman,Rob M F Wolthuis,Patrick Cramer,Orlando D Schärer,Goran Kokic,Jesper Q Svejstrup,Martijn S Luijsterburg

Evaluation of STK17B as a cancer immunotherapy target utilizing highly potent and selective small molecule inhibitors

利用高效选择性小分子抑制剂评估STK17B作为癌症免疫治疗靶点的价值

Felix Scheuplein ,Florian Renner ,John E Campbell ,Robert Campbell ,Chris De Savi ,Jan Eckmann ,Holger Fischer ,Jie Ge ,Luke Green ,Peter Jakob ,Joseph L Kim ,Caitlin Kinkema ,Katie McGinn ,Ricardo Medina ,Annemarie Müller ,Nisha Perez ,Emanuele Perola ,Yoav Timsit ,Tary Traore ,Ulrike Hopfer ,Stefka Tyanova ,Manuel Tzouros ,Ruduan Wang ,Richard Woessner ,Marion Dorsch ,James R Bischoff

PFTK1 kinase regulates axogenesis during development via RhoA activation

PFTK1激酶通过激活RhoA来调控发育过程中的轴突发生。

Yasmilde Rodríguez González ,Fatemeh Kamkar ,Paymaan Jafar-Nejad ,Suzi Wang ,Dianbo Qu ,Leticia Sanchez Alvarez ,Dina Hawari ,Margaret Sonnenfeld ,Ruth S Slack ,Paul R Albert ,David S Park ,Alvin Joselin

AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

AXL靶向治疗通过扩增TCF1+ CD8 T细胞恢复STK11/LKB1突变型非小细胞肺癌对PD-1阻断的敏感性

Huiyu Li,Zhida Liu,Longchao Liu,Hongyi Zhang,Chuanhui Han,Luc Girard,Hyunsil Park,Anli Zhang,Chunbo Dong,Jianfeng Ye,Austin Rayford,Michael Peyton,Xiaoguang Li,Kimberley Avila,Xuezhi Cao,Shuiqing Hu,Md Maksudul Alam,Esra A Akbay,Luisa M Solis,Carmen Behrens,Sharia Hernandez-Ruiz,Wei Lu,Ignacio Wistuba,John V Heymach,Michael Chisamore,David Micklem,Hani Gabra,Gro Gausdal,James B Lorens,Bo Li,Yang-Xin Fu,John D Minna,Rolf A Brekken

LKB1/ STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms

LKB1/STK11是骨髓增生性肿瘤进展中的抑癌基因

Christian Marinaccio # ,Praveen Suraneni # ,Hamza Celik ,Andrew Volk ,Qiang Jeremy Wen ,Te Ling ,Marinka Bulic ,Terra Lasho ,Richard P Koche ,Christopher A Famulare ,Noushin Farnoud ,Brady Stein ,Michael Schieber ,Sandeep Gurbuxani ,David E Root ,Scott T Younger ,Ronald Hoffman ,Naseema Gangat ,Panagiotis Ntziachristos ,Navdeep S Chandel ,Ross L Levine ,Raajit K Rampal ,Grant A Challen ,Ayalew Tefferi ,John D Crispino

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

证据表明 STK19 并非 NRAS 依赖性黑色素瘤驱动基因。

Marta Rodríguez-Martínez,Thierry Boissiére,Melvin Noe Gonzalez,Kevin Litchfield,Richard Mitter,Jane Walker,Svend Kjœr,Mohamed Ismail,Julian Downward,Charles Swanton,Jesper Q Svejstrup

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

STK11 和 KEAP1 的共突变促进肺癌中的铁死亡保护和 SCD1 依赖性

Corrin A Wohlhieter ,Allison L Richards ,Fathema Uddin ,Christopher H Hulton ,Àlvaro Quintanal-Villalonga ,Axel Martin ,Elisa de Stanchina ,Umeshkumar Bhanot ,Marina Asher ,Nisargbhai S Shah ,Omar Hayatt ,Darren J Buonocore ,Natasha Rekhtman ,Ronglai Shen ,Kathryn C Arbour ,Mark Donoghue ,John T Poirier ,Triparna Sen ,Charles M Rudin

A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma

一种基于纳米串的敏感检测方法用于评估肺腺癌中 STK11 (LKB1) 通路的紊乱情况

Lu Chen ,Brienne E Engel ,Eric A Welsh ,Sean J Yoder ,Stephen G Brantley ,Dung-Tsa Chen ,Amer A Beg ,Chunxia Cao ,Frederic J Kaye ,Eric B Haura ,Matthew B Schabath ,W Douglas Cress

Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma

PFTK1 过表达预示着食管鳞状细胞癌患者对化疗的耐药性

H Miyagaki ,M Yamasaki, H Miyata, T Takahashi, Y Kurokawa, K Nakajima, S Takiguchi, Y Fujiwara, H Ishii, F Tanaka, M Mori, Y Doki