HMG相关文献与解析，生知库 | 链接生命科学的每一步

Sung Wook Son # ，Hyo-Jung Lee # ，NaNa Kang ，Seongjae Bae ，Eunho Cho ，Heeju Kwon ，Da-Young Yoon ，Chaeleen Lee ，Seungho Lee ，Min Kyu Son ，Jisu Chae ，Suyeon Kim ，Se Jin Oh ，Younji Sim ，Kyung-Mi Lee ，Cassian Yee ，Seon Rang Woo ，Yun-Jeong Jeong ，Hee-Jung Choi ，Jong-Young Kwak ，Eun-Woo Lee ，Jinuk Park ，Sang Gyu Kwak ，Young-Chae Chang ，Tae Woo Kim ，Kwon-Ho Song

免疫/内分泌

肿瘤

E2F1

High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

高迁移率族蛋白A1 (HMGA1) 通过抑制STING介导的抗肿瘤免疫促进食管鳞状细胞癌的进展

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-025-60221-6

Kai-Yue He ，Annie Zhao ，Jin-Rong Guo ，Dan-Hui Wu ，Huai Liu ，Fan Gao ，Meng-Jie Liu ，Jing-Yu Yang ，Xin-Yuan Lei ，Jun-Qi Li ，Lei Zhang ，Zhen-Hua Yan ，Qiang Ding ，Yong-Wei Huang ，Rutao Cui ，Yong-Ping Jian ，Zhi-Xiang Xu

Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma

靶向HMGB2可通过增强CD8+ T细胞功能和抑制肝细胞癌肿瘤生长发挥双重免疫调节作用。

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.ads8597

Wei-Feng Qu ，Gui-Qi Zhu ，Rui Yang ，Tian-Hao Chu ，Zhi-Qi Guan ，Run Huang ，Meng-Xin Tian ，Xi-Fei Jiang ，Chen-Yang Tao ，Yuan Fang ，Jun Gao ，Xiao-Ling Wu ，Jia-Feng Chen ，Qian-Fu Zhao ，Yi Wang ，Yi-Chao Bu ，Jian Zhou ，Jia Fan ，Wei-Ren Liu ，Zheng Tang ，Ying-Hong Shi

HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma

HMGA2表达可预测胰腺导管腺癌的亚型、生存期和治疗结果

期刊:Clinical Cancer Research

影响因子:10

doi:10.1158/1078-0432.CCR-24-2200

Naomi Yamamoto ，Stephanie Dobersch ，Ian Loveless ，Annie N Samraj ，Gun Ho Jang ，Miki Haraguchi ，Liang-I Kang ，Marianna B Ruzinova ，Kiran R Vij ，Jacqueline L Mudd ，Thomas Walsh ，Rachael A Safyan ，Elena Gabriela Chiorean ，Sunil R Hingorani ，Nathan M Bolton ，Li Li ，Ryan C Fields ，David G DeNardo ，Faiyaz Notta ，Howard C Crawford ，Nina G Steele ，Sita Kugel

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

跨物种比较表明，Hmga1通过降低H3K27me3水平来促进心肌细胞增殖和心脏再生。

期刊:Nature Cardiovascular Research

影响因子:9.4

doi:10.1038/s44161-024-00588-9

Mara Bouwman # ，Dennis E M de Bakker # ，Hessel Honkoop ，Alexandra E Giovou ，Danielle Versteeg ，Arie R Boender ，Phong D Nguyen ，Merel Slotboom ，Daniel Colquhoun ，Marta Vigil-Garcia ，Lieneke Kooijman ，Rob Janssen ，Ingeborg B Hooijkaas ，Marie Günthel ，Kimberly J Visser ，Mischa Klerk ，Lorena Zentilin ，Mauro Giacca ，Jan Kaslin ，Gerard J J Boink ，Eva van Rooij ，Vincent M Christoffels ，Jeroen Bakkers

细胞生物学

发表日期：2025

文献求助收藏

dsHMGB1, released from IL-17A-induced pyroptotic prostate epithelial cells, drives M1 polarization by promoting Pfkp-mediated glycolysis via Jak2/Stat1 transcription in experimental autoimmune prostatitis

dsHMGB1由IL-17A诱导的焦亡前列腺上皮细胞释放，通过促进Pfkp介导的糖酵解（经由Jak2/Stat1转录）驱动实验性自身免疫性前列腺炎中的M1极化。

期刊:International Journal of Biological Sciences

影响因子:8.2

doi:10.7150/ijbs.113908

Wenming Ma ，Yi Zhang ，Wenlong Xu ，Yongtao Hu ，Weikang Wu ，Lei Chen ，Li Zhang ，Hexi Du ，Jialin Meng ，Jing Chen ，Chaozhao Liang

Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer's disease by regulating microglia homeostasis and inhibiting HMGB1 pathway

δ-阿片受体信号通路通过调节小胶质细胞稳态和抑制HMGB1通路，减轻阿尔茨海默病小鼠模型中的神经病理学改变和认知障碍。

期刊:Alzheimers Research & Therapy

影响因子:7.9

doi:10.1186/s13195-025-01682-1

Yuan Xu ，Naiyuan Shao ，Feng Zhi ，Ronghua Chen ，Yilin Yang ，Jiahui Li ，Ying Xia ，Ya Peng

HMGB1 couples LEF1 to regulate B cell immunity

HMGB1 与 LEF1 结合以调节 B 细胞免疫

期刊:JCI Insight

影响因子:6.3

doi:10.1172/jci.insight.187002

Qiuyue Chen,Ziyin Zhang,Nanshu Xiang,Li Luo,Xin Dai,Danqing Kang,Lu Yang,Yingzi Zhu,Jiang Chang,Yukai Jing,Na Li,Qianglin Chen,Panpan Jiang,Ju Liu,Yanmei Huang,Heather Miller,Xinyuan Zhou,Fang Zheng,Quan Gong,Chaohong Liu

NK cell function down regulated by HMGB2 through ANGPT1/PI3K/AKT pathway and its effect on esophageal squamous carcinoma cells

HMGB2通过ANGPT1/PI3K/AKT通路下调NK细胞功能及其对食管鳞状细胞癌细胞的影响

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1666199

Xiaodi Yin # ，Huihong Cai # ，Aohua Zhang ，Weihan Zheng ，Jiahui Zhao ，Jun Ma

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

HMGN2 缺乏通过促进 H3 组蛋白修饰介导的 CD14/iNOS 表达来增强巨噬细胞的抗菌活性。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1621440

Zhen Yang # ，Xiao Zhang # ，Chaoqun Liu ，Ning Huang ，Yan Teng ，Junming Miao

The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells

E2F1-HMGCR轴促进免疫难治性肿瘤细胞的铁死亡抵抗。

High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity

高迁移率族蛋白A1 (HMGA1) 通过抑制STING介导的抗肿瘤免疫促进食管鳞状细胞癌的进展

Targeting HMGB2 acts as dual immunomodulator by bolstering CD8+ T cell function and inhibiting tumor growth in hepatocellular carcinoma

靶向HMGB2可通过增强CD8+ T细胞功能和抑制肝细胞癌肿瘤生长发挥双重免疫调节作用。

HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma

HMGA2表达可预测胰腺导管腺癌的亚型、生存期和治疗结果

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

跨物种比较表明，Hmga1通过降低H3K27me3水平来促进心肌细胞增殖和心脏再生。

dsHMGB1, released from IL-17A-induced pyroptotic prostate epithelial cells, drives M1 polarization by promoting Pfkp-mediated glycolysis via Jak2/Stat1 transcription in experimental autoimmune prostatitis

dsHMGB1由IL-17A诱导的焦亡前列腺上皮细胞释放，通过促进Pfkp介导的糖酵解（经由Jak2/Stat1转录）驱动实验性自身免疫性前列腺炎中的M1极化。

Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer's disease by regulating microglia homeostasis and inhibiting HMGB1 pathway

δ-阿片受体信号通路通过调节小胶质细胞稳态和抑制HMGB1通路，减轻阿尔茨海默病小鼠模型中的神经病理学改变和认知障碍。

HMGB1 couples LEF1 to regulate B cell immunity

HMGB1 与 LEF1 结合以调节 B 细胞免疫

NK cell function down regulated by HMGB2 through ANGPT1/PI3K/AKT pathway and its effect on esophageal squamous carcinoma cells

HMGB2通过ANGPT1/PI3K/AKT通路下调NK细胞功能及其对食管鳞状细胞癌细胞的影响

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

HMGN2 缺乏通过促进 H3 组蛋白修饰介导的 CD14/iNOS 表达来增强巨噬细胞的抗菌活性。