日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells

BET降解剂揭示BRD4对7SK和P-TEFb的破坏对于CD4+ T细胞中潜伏HIV的有效激活至关重要。

Anne-Marie W Turner ,Frances M Bashore ,Shane D Falcinelli ,Joshua A Fox ,Alana L Keller ,Anthony D Fenton ,Renee F Geyer ,Brigitte Allard ,Jennifer L Kirchherr ,Nancie M Archin ,Lindsey I James ,David M Margolis

Stefin B alleviates the gouty arthritis in mice by inducing the M2 polarization of macrophages

Stefin B 通过诱导巨噬细胞 M2 极化来缓解小鼠痛风性关节炎。

Shishui Lin ,Xu Hu ,Yang Li ,Jiyue Huang ,Rui Zhang ,Xinxin Bai ,Shaohuang Weng ,Min Chen

MyD88-dependent Toll-like receptor 2 signaling modulates macrophage activation on lysate-adsorbed Teflon™ AF surfaces in an in vitro biomaterial host response model

在体外生物材料宿主反应模型中,MyD88依赖的Toll样受体2信号通路调节裂解物吸附的Teflon™ AF表面上的巨噬细胞活化。

Laura A McKiel ,Laurel L Ballantyne ,Gian Luca Negri ,Kimberly A Woodhouse ,Lindsay E Fitzpatrick

Dynamic regulation of P-TEFb by 7SK snRNP is integral to the DNA damage response to regulate chemotherapy sensitivity

7SK snRNP 对 P-TEFb 的动态调控是 DNA 损伤反应中不可或缺的一部分,进而调节化疗敏感性。

Yin Fang ,Yan Wang ,Benjamin M Spector ,Xue Xiao ,Chao Yang ,Ping Li ,Yuan Yuan ,Ping Ding ,Zhi-Xiong Xiao ,Peixuan Zhang ,Tong Qiu ,Xiaofeng Zhu ,David H Price ,Qintong Li

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

HBO1-MLL相互作用促进AF4/ENL/P-TEFb介导的白血病发生

Satoshi Takahashi ,Akinori Kanai ,Hiroshi Okuda ,Ryo Miyamoto ,Yosuke Komata ,Takeshi Kawamura ,Hirotaka Matsui ,Toshiya Inaba ,Akifumi Takaori-Kondo ,Akihiko Yokoyama

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

TRIM28 通过 SUMO 化 CDK9 和抑制 P-TEFb 来促进 HIV-1 潜伏。

Xiancai Ma ,Tao Yang ,Yuewen Luo ,Liyang Wu ,Yawen Jiang ,Zheng Song ,Ting Pan ,Bingfeng Liu ,Guangyan Liu ,Jun Liu ,Fei Yu ,Zhangping He ,Wanying Zhang ,Jinyu Yang ,Liting Liang ,Yuanjun Guan ,Xu Zhang ,Linghua Li ,Weiping Cai ,Xiaoping Tang ,Song Gao ,Kai Deng ,Hui Zhang

Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

巨核细胞和血小板表达的半胱氨酸蛋白酶stefin A和cystatin A水平升高可预防血栓形成。

Anna Mezzapesa ,Delphine Bastelica ,Lydie Crescence ,Marjorie Poggi ,Michel Grino ,Franck Peiretti ,Laurence Panicot-Dubois ,Annabelle Dupont ,René Valero ,Marie Maraninchi ,Jean-Claude Bordet ,Marie-Christine Alessi ,Christophe Dubois ,Matthias Canault

The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition

过度活跃结构的建立使得肿瘤抑制蛋白p53能够在CDK9激酶抑制有限的情况下通过P-TEFb发挥功能。

Thomas K Albert ,Claudia Antrecht ,Elisabeth Kremmer ,Michael Meisterernst