日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

磷酸酶PTPN22在mTORC2复合物中发挥接头蛋白的作用。

Keshav Gupta ,Nagalakshmi Kommineni ,Tanuja Bogadi ,Neeraja P Alamuru-Yellapragada ,Subbareddy Maddika

Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition

揭示PTPN1和PTPN2在T细胞双重抑制过程中各自的免疫治疗作用

Luis-Alberto Perez-Quintero ,Alexandre J Poirier ,Chu-Han Feng ,Zuzet Martinez-Cordova ,Isabelle Aubry ,Cedric Carli ,Samaneh Kamyabiazar ,Alain Pacis ,Yevgen Zolotarov ,Kelly-Anne Pike ,Jean-Sébastien Delisle ,Michel L Tremblay

Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression

雄激素通过T细胞内在的Ptpn22磷酸酶表达调控,导致小鼠自身免疫性疾病的性别偏倚。

Jean Lee ,Leonid A Yurkovetskiy ,Derek Reiman ,Lara Frommer ,Zoe Strong ,Anthony Chang ,George J Kahaly ,Aly A Khan ,Alexander V Chervonsky

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus

PTPN2基因单倍体不足会导致从埃文斯综合征到狼疮等早期发作的系统性自身免疫性疾病。

Marie Jeanpierre # ,Jade Cognard # ,Maud Tusseau ,Quentin Riller ,Linh-Chi Bui ,Jérémy Berthelet ,Audrey Laurent ,Etienne Crickx ,Marianna Parlato ,Marie-Claude Stolzenberg ,Felipe Suarez ,Guy Leverger ,Nathalie Aladjidi ,Sophie Collardeau-Frachon ,Christine Pietrement ,Marion Malphettes ,Antoine Froissart ,Christine Bole-Feysot ,Nicolas Cagnard ,Fernando Rodrigues Lima ,Thierry Walzer ,Frédéric Rieux-Laucat # ,Alexandre Belot # ,Anne-Laure Mathieu #

Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy

树突状细胞固有蛋白PTPN22负向调控抗肿瘤免疫,并影响抗PD-L1疗效。

Santiago Acero-Bedoya ,Emily F Higgs ,Anna C Martinez ,Ruxandra Tonea ,Thomas F Gajewski

The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2

HIV潜伏期逆转剂HODHBt抑制磷酸酶PTPN1和PTPN2。

J Natalie Howard ,Thomas D Zaikos ,Callie Levinger ,Esteban Rivera ,Elyse K McMahon ,Carissa S Holmberg ,Joshua Terao ,Marta Sanz ,Dennis C Copertino Jr ,Weisheng Wang ,Natalia Soriano-Sarabia ,R Brad Jones ,Alberto Bosque

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

PTPN2/PTPN1抑制剂ABBV-CLS-484可释放强大的抗肿瘤免疫力。

Christina K Baumgartner # ,Hakimeh Ebrahimi-Nik # ,Arvin Iracheta-Vellve ,Keith M Hamel ,Kira E Olander ,Thomas G R Davis ,Kathleen A McGuire ,Geoff T Halvorsen ,Omar I Avila ,Chirag H Patel ,Sarah Y Kim ,Ashwin V Kammula ,Audrey J Muscato ,Kyle Halliwill ,Prasanthi Geda ,Kelly L Klinge ,Zhaoming Xiong ,Ryan Duggan ,Liang Mu ,Mitchell D Yeary ,James C Patti ,Tyler M Balon ,Rebecca Mathew ,Carey Backus ,Domenick E Kennedy ,Angeline Chen ,Kenton Longenecker ,Joseph T Klahn ,Cara L Hrusch ,Navasona Krishnan ,Charles W Hutchins ,Jax P Dunning ,Marinka Bulic ,Payal Tiwari ,Kayla J Colvin ,Cun Lan Chuong ,Ian C Kohnle ,Matthew G Rees ,Andrew Boghossian ,Melissa Ronan ,Jennifer A Roth ,Meng-Ju Wu ,Juliette S M T Suermondt ,Nelson H Knudsen ,Collins K Cheruiyot ,Debattama R Sen ,Gabriel K Griffin ,Todd R Golub ,Nabeel El-Bardeesy ,Joshua H Decker ,Yi Yang ,Magali Guffroy ,Stacey Fossey ,Patricia Trusk ,Im-Meng Sun ,Yue Liu ,Wei Qiu ,Qi Sun ,Marcia N Paddock ,Elliot P Farney ,Mark A Matulenko ,Clay Beauregard ,Jennifer M Frost # ,Kathleen B Yates # ,Philip R Kym # ,Robert T Manguso #

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

PTP1B 和 PTPN2 的小分子抑制剂可增强 T 细胞抗肿瘤免疫力。

Shuwei Liang # ,Eric Tran # ,Xin Du ,Jiajun Dong ,Harrison Sudholz ,Hao Chen ,Zihan Qu ,Nicholas D Huntington ,Jeffrey J Babon ,Nadia J Kershaw ,Zhong-Yin Zhang ,Jonathan B Baell ,Florian Wiede ,Tony Tiganis

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

T细胞中PTPN22 R620W基因编辑增强低亲和力TCR反应

Warren Anderson ,Fariba Barahmand-Pour-Whitman ,Peter S Linsley ,Karen Cerosaletti ,Jane H Buckner ,David J Rawlings

PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer

PTPN2 在三阴性乳腺癌中对肿瘤免疫产生细胞自主性和非细胞自主性效应

Pei Kee Goh ,Florian Wiede ,Mara N Zeissig ,Kara L Britt ,Shuwei Liang ,Tim Molloy ,Nathan Goode ,Rachel Xu ,Sherene Loi ,Mathias Muller ,Patrick O Humbert ,Catriona McLean ,Tony Tiganis