日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway

外周T细胞淋巴瘤中的JAK3 A573V和JAK3 M511I突变通过STAT3/PD-L1通路介导对PD-1抑制剂的耐药性。

Ning Lou # ,Mengwei Yang # ,Zucheng Xie # ,Ruyun Gao # ,Lei Zhang ,Le Tang ,Jiarui Yao ,Xiaohong Han ,Yuankai Shi

Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway

褪黑素通过JAK3-STAT5信号通路增加T-bet表达,从而增强老年小鼠的NK细胞功能。

Caiying Liang ,Rongrong Song ,Jieyu Zhang ,Jie Yao ,Ziyun Guan ,Xiaokang Zeng

Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress

基因敲入 EIF2AK3 变体揭示了内质网应激下小鼠肝脏和胰腺中 PERK 活性的差异。

Shivesh Ghura ,Noah R Beratan ,Xinglong Shi ,Elena Alvarez-Periel ,Sarah E Bond Newton ,Cagla Akay-Espinoza ,Kelly L Jordan-Sciutto

Restored autophagy is protective against PAK3-induced cardiac dysfunction

自噬功能的恢复可保护心脏免受PAK3诱导的功能障碍的影响

Andrea Ruiz-Velasco ,Rida Raja ,Xinyi Chen ,Haresh Ganenthiran ,Namrita Kaur ,Nasser Hawimel O Alatawi ,Jessica M Miller ,Riham R E Abouleisa ,Qinghui Ou ,Xiangjun Zhao ,Oveena Fonseka ,Xin Wang ,Susanne S Hille ,Norbert Frey ,Tao Wang ,Tamer M A Mohamed ,Oliver J Müller ,Elizabeth J Cartwright ,Wei Liu

IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis

IRAK3介导的促炎性MyD88/IRAK信号通路抑制影响急性胰腺炎的疾病严重程度

Franziska G Thiel ,Saeedeh Asgarbeik ,Juliane Glaubitz ,Anika Wilden ,Markus M Lerch ,Frank Ulrich Weiss ,Matthias Sendler

Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases

JAK3抑制剂抑制NK细胞活化:在自身免疫性疾病治疗中的意义

Wai Chung Wu ,Carol Shiu ,Tak Keung Tong ,Shui On Leung ,Chin Wai Hui

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

IRF4 缺陷通过体细胞获得的 Jak3 突变赋予 IL-7 超敏反应,使 B 细胞后代易患白血病。

Dennis Das Gupta ,Christoph Paul ,Nadine Samel ,Maria Bieringer ,Daniel Staudenraus ,Federico Marini ,Hartmann Raifer ,Lisa Menke ,Lea Hansal ,Bärbel Camara ,Edith Roth ,Patrick Daum ,Michael Wanzel ,Marco Mernberger ,Andrea Nist ,Uta-Maria Bauer ,Frederik Helmprobst ,Malte Buchholz ,Katrin Roth ,Lorenz Bastian ,Alina M Hartmann ,Claudia Baldus ,Koichi Ikuta ,Andreas Neubauer ,Andreas Burchert ,Hans-Martin Jäck ,Matthias Klein ,Tobias Bopp ,Thorsten Stiewe ,Axel Pagenstecher ,Michael Lohoff

A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal

一种高选择性JAK3抑制剂被开发用于治疗类风湿性关节炎,其作用机制是通过抑制γc细胞因子相关的JAK-STAT信号通路。

Chengjuan Chen ,Yuan Yin ,Gaona Shi ,Yu Zhou ,Shuai Shao ,Yazi Wei ,Lei Wu ,Dayong Zhang ,Lan Sun ,Tiantai Zhang

Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments

Jak3在肥胖相关认知障碍中的机制作用

Premranjan Kumar ,Jayshree Mishra ,Narendra Kumar

Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata

选择性抑制JAK3信号通路足以逆转斑秃

Zhenpeng Dai ,James Chen ,Yuqian Chang ,Angela M Christiano