日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results

靶向淋巴结的mKRAS特异性两亲性疫苗治疗胰腺癌和结直肠癌:AMPLIFY-201 I期试验最终结果

Zev A Wainberg ,Colin D Weekes ,Muhammad Furqan ,Pashtoon M Kasi ,Craig E Devoe ,Alexis D Leal ,Vincent Chung ,James R Perry ,Thian Kheoh ,Lisa K McNeil ,Esther Welkowsky ,Peter C DeMuth ,Christopher M Haqq ,Shubham Pant # ,Eileen M O'Reilly #

Mutant KRAS peptide targeted CAR-T cells engineered for cancer therapy

用于癌症治疗的靶向突变型KRAS肽的CAR-T细胞

Alexander Benton ,Jiageng Liu ,Mathilde A Poussin ,Andrea Lang Goldgewicht ,Madhara Udawela ,Adham S Bear ,Nils Wellhausen ,Beatriz M Carreno ,Pete M Smith ,Matthew D Beasley ,Ben R Kiefel ,Daniel J Powell Jr

A first-in-class EGFR-directed KRAS G12V selective inhibitor

首创的EGFR靶向KRAS G12V选择性抑制剂

Lyla J Stanland ,Hayden P Huggins ,Snehasudha S Sahoo ,Alessandro Porrello ,Yogitha Chareddy ,Salma H Azam ,Jillian L Perry ,Pradeep S Pallan ,Kristina Whately ,Lincy Edatt ,William D Green ,Matthew C Fleming ,Jonah Im ,Christina Gutierrez-Ford ,Imani Simmons ,Alyaa Dawoud ,Katherine I Zhou ,Vandanaa Jayaprakash ,Rani S Sellers ,Gabriela de la Cruz ,Albert Wielgus ,Justin Milner ,Martin Egli ,Albert A Bowers ,Chad V Pecot

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers

追踪Kras驱动癌症中单细胞3D基因组的演变

Miao Liu # ,Shengyan Jin # ,Sherry S Agabiti # ,Tyler B Jensen ,Tianqi Yang ,Jonathan S D Radda ,Christian F Ruiz ,Gabriel Baldissera ,Moein Rajaei ,Fang-Yong Li ,Jeffrey P Townsend ,Mandar Deepak Muzumdar ,Siyuan Wang

A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

转分化和程序性细胞死亡启动之间的一个决定点控制着KRAS依赖性胰腺癌的发展。

Anne T Schneider ,Christiane Koppe ,Emilie Crouchet ,Aristeidis Papargyriou ,Michael T Singer ,Veronika Büttner ,Leonie Keysberg ,Marta Szydlowska ,Frank Jühling ,Julien Moehlin ,Min-Chun Chen ,Valentina Leone ,Sebastian Mueller ,Thorsten Neuß ,Mirco Castoldi ,Marina Lesina ,Frank Bergmann ,Thilo Hackert ,Katja Steiger ,Wolfram T Knoefel ,Alex Zaufel ,Jakob N Kather ,Irene Esposito ,Matthias M Gaida ,Ahmed Ghallab ,Jan G Hengstler ,Henrik Einwächter ,Kristian Unger ,Hana Algül ,Nikolaus Gassler ,Roland M Schmid ,Roland Rad ,Thomas F Baumert ,Maximilian Reichert ,Mathias Heikenwalder ,Vangelis Kondylis # ,Mihael Vucur # ,Tom Luedde #

Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma

野生型KRAS激活驱动肝细胞癌逃避干扰素介导的免疫反应并产生免疫治疗耐药性。

Martina Mang Leng Lei ,Carmen Oi Ning Leung ,Rainbow Wing Hei Leung ,Xue Qian Wu ,Katherine Po Sin Chung ,Catherine Yu Jia Gu ,Mandy Sze Man Chan ,Wing Ki Chau ,Quan Hua Mu ,Kai Yu Ng ,Man Tong ,Jing Ping Yun ,Jia Ming Nickolas Teo ,Guang Sheng Ling ,Patrick Pak Chun Wong ,Stephen Lam Chan ,Zhe Wen Xiong ,Alfred Sze Lok Cheng ,Jin Ding ,Stephanie Ma ,Terence Kin Wah Lee

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

LKB1调控JNK依赖性应激信号传导和KRAS突变型肺癌的凋亡依赖性

Chendi Li ,Mohammed Usman Syed ,Anahita Nimbalkar ,Yi Shen ,Melissa D Vieira ,Cameron Fraser ,Zintis Inde ,Xingping Qin ,Jian Ouyang ,Johannes Kreuzer ,Sarah E Clark ,Grace Kelley ,Emily M Hensley ,Robert Morris ,Raul Lazaro ,Brian Belmonte ,Audris Oh ,Makeba Walcott ,Christopher S Nabel ,Sean Caenepeel ,Anne Y Saiki ,Karen Rex ,J Russell Lipford ,Rebecca S Heist ,Jessica J Lin ,Wilhelm Haas ,Kristopher Sarosiek ,Paul E Hughes ,Aaron N Hata

Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer

乳酸脱氢酶B以非经典途径促进KRAS驱动的肺癌中的铁死亡防御

Liang Zhao # ,Haibin Deng # ,Jingyi Zhang ,Nicola Zamboni ,Haitang Yang ,Yanyun Gao ,Zhang Yang ,Duo Xu ,Haiqing Zhong ,Geert van Geest ,Rémy Bruggmann ,Qinghua Zhou ,Ralph A Schmid ,Thomas M Marti ,Patrick Dorn ,Ren-Wang Peng

Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS-mutant cancer models

利用小分子靶向非泛素依赖性蛋白酶体可增加泛KRAS突变癌症模型的敏感性

Shihui Shen ,Qiansen Zhang ,Yuhan Wang ,Hui Chen ,Shuangming Gong ,Yun Liu ,Conghao Gai ,Hansen Chen ,Enhao Zhu ,Bo Yang ,Lin Liu ,Siyuan Cao ,Mengting Zhao ,Wenjie Ren ,Mengjuan Li ,Zhuoya Peng ,Lu Zhang ,Shaoying Zhang ,Juwen Shen ,Bianhong Zhang ,Patrick Kh Lee ,Kun Li ,Lei Li ,Huaiyu Yang

SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer

SMAD4 和 KRAS 状态影响胰腺癌中癌细胞-基质相互作用和治疗反应

Eloise G Lloyd ,Muntadher Jihad ,Judhell S Manansala ,Wenlong Li ,Priscilla S W Cheng ,Gianluca Mucciolo ,Marta Zaccaria ,Sara Pinto Teles ,Joaquín Araos Henríquez ,Sneha Harish ,Rebecca Brais ,Sally Ashworth ,Weike Luo ,Paul M Johnson ,Lisa Veghini ,Mireia Vallespinos ,Vincenzo Corbo ,Giulia Biffi