日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3

维生素A及其类似物通过直接靶向ACSL3来调节单不饱和脂肪酸（MUFA）代谢，从而改善铁死亡和衰老。

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2025.11.004
Luo, Nanxuan; Xiao, Yijie; Zhai, Yile; Li, Jie; Lv, Lijie; Yin, Houhua; Lin, Fang; Wan, Biwen; Zhang, Ke; Hu, Junchi; Liu, Junyan; Dang, Yongjun; He, Yi; Zhao, Yahui; Zhang, Zhe; Nie, Shenyou; Yuan, Hai-Xin
铁死亡
衰老
ACSL3
代谢
发表日期：2026
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Genome-wide CRISPR screen identifies ACSL3 as a regulator of lipotoxicity and progression of MASLD

全基因组 CRISPR 筛选鉴定出 ACSL3 是脂毒性和 MASLD 进展的调节因子

期刊:Hepatology Communications
影响因子:5.6
doi:10.1097/HC9.0000000000000884.
Yuta Myojin,Takahiro Kodama,Ryo Takahashi,Hideharu Nagasawa,Yasuteru Kondo,Kosuke Yusa,Tomomi Yoshida-Hashidate,Hideo Shindou,Kunimaro Furuta,Kazuhiro Murai,Yoshinobu Saito,Hayato Hikita,Tetsuo Takehara
毒理研究
ACSL3
Mas
发表日期：2026
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ACSL3 Promotes Hepatocellular Carcinoma Tumorigenesis and Correlates With JAK-STAT3 Signaling

ACSL3促进肝细胞癌的肿瘤发生，并与JAK-STAT3信号通路相关

期刊:Cancer Medicine
影响因子:3.1
doi:10.1002/cam4.71543
Amelimojarad, Melika; Amelimojarad, Mandana; Pourmahdian, Alireza; Lu, Zhang
肿瘤
肿瘤免疫
JAK/STAT
信号转导
STAT3
ACSL3
细胞生物学
发表日期：2026
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Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

利用纳米颗粒（NPs）介导的ACSL3沉默调节脂质代谢，从而抑制肝细胞癌的生长和转移

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02274-1
Huang, Linzhuo; Xu, Rui; Chen, Siyu; Lin, Chunhao; Li, Wende; Li, Senlin; Saw, Phei Er; Zhang, Lei; Xu, Xiaoding
肿瘤
肿瘤免疫
代谢
ACSL3
细胞生物学
发表日期：2025
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UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage-to-Myofibroblast Transition in Chronic Pancreatitis

UCP2上调ACSL3以增强腺泡细胞脂滴释放，并调节Sirt1/Smad3通路以促进慢性胰腺炎中巨噬细胞向肌成纤维细胞的转化

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202412571
Wang, Kunpeng; Zhang, Lilong; Deng, Beiying; Jiang, Wanrong; Kuang, Tianrui; Chen, Chen; Zhao, Kailiang; Shi, Qiao; He, Jun; Wang, Weixing
巨噬细胞
成纤维细胞
胰腺炎
信号转导
巨噬细胞
ACSL3
UCP2
细胞生物学
免疫/内分泌
发表日期：2025
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Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3

单不饱和脂肪酸通过ACSL3抑制铁死亡，从而促进癌症放射抗性。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07516-0
Cao, Yulin; Li, Jiuming; Chen, Ying; Wang, Yuanben; Liu, Zhiang; Huang, Liuying; Liu, Bingxin; Feng, Yuyang; Yao, Surui; Zhou, Leyuan; Yin, Yuan; Huang, Zhaohui
肿瘤
肿瘤免疫
铁死亡
代谢
ACSL3
发表日期：2025
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Correction: Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3

更正：单不饱和脂肪酸通过ACSL3抑制铁死亡，从而促进癌症放射抗性。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07726-6
Cao, Yulin; Li, Jiuming; Chen, Ying; Wang, Yuanben; Liu, Zhiang; Huang, Liuying; Liu, Bingxin; Feng, Yuyang; Yao, Surui; Zhou, Leyuan; Yin, Yuan; Huang, Zhaohui
肿瘤
肿瘤免疫
铁死亡
代谢
ACSL3
发表日期：2025
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Commentary: Transcription factor MEF2D regulates aberrant expression of ACSL3 and enhances sorafenib resistance by inhibiting ferroptosis in HCC

评论：转录因子MEF2D通过抑制铁死亡调控ACSL3的异常表达，增强肝细胞癌的索拉非尼耐药性。

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2025.1575998
Chen, Xiaoyan; Xie, Jin; Fan, Wei; Zhang, Junfeng; Gao, Feng; Li, Zhi
肿瘤
肿瘤免疫
信号转导
铁死亡
ACSL3
细胞生物学
发表日期：2025
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Lipid Metabolism Related Gene ACSL3 as a Biomarker for Predicting Immunotherapy Outcomes in Lung Adenocarcinoma

脂质代谢相关基因ACSL3作为预测肺腺癌免疫治疗疗效的生物标志物

期刊:Cancer Research and Treatment
影响因子:3.8
doi:10.4143/crt.2024.1119
He, Taiping; Hu, Jinhan; Guo, Haoyue; Diao, Meng; Wang, Yuanyuan; Wu, Yuhan; Cheng, Lei; Zhao, Chao; Li, Xuefei; Zhou, Caicun
肿瘤
肿瘤免疫
代谢
ACSL3
免疫/内分泌
发表日期：2025
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Multidimensional analysis reveals the potential of ACSL3 as a cancer biomarker: from pan-cancer exploration to functional validation in hepatocellular carcinoma

多维分析揭示了ACSL3作为癌症生物标志物的潜力：从泛癌探索到肝细胞癌的功能验证

期刊:Clinical and Experimental Medicine
影响因子:3.5
doi:10.1007/s10238-025-01882-x
Niu, Qun; Mou, Yu; Yao, Yuanqian; Dong, HaiJian; Wang, Kaixin; Zeng, Zijian; Tao, Yujing; Gong, Xueqing; Li, Hui
细胞生物学
肿瘤
肿瘤免疫
ACSL3
发表日期：2025
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