日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b(+) Bregs thereby overcoming melanoma PD1-resistance

RAS/MEK/PI3K通路抑制通过靶向CD11b(+) Bregs增强对CD40激动剂的反应，从而克服黑色素瘤PD1耐药性。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-67315-1
Yan, Chi; Luo, Weifeng; Yang, Jinming; Yang, Jing; Chen, Sheau-Chiann; Bergdorf, Kensey; Hu, Qianni; Weiss, Vivian L; Johnson, Douglas B; Liu, Qi; Richmond, Ann
黑色素瘤
T细胞
信号转导
CD40
RAS
CD4
发表日期：2026
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Repression of miR-29 via MYC leads to increased CD40 signaling in transformed follicular lymphoma

MYC介导的miR-29抑制导致转化型滤泡性淋巴瘤中CD40信号增强

期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-026-02868-8
Filip, Daniel; Litzmanova, Katerina; Michaelou, Androniki; Kledus, Filip; Devan, Jan; Boudny, Miroslav; Hoferkova, Eva; Sharma, Sonali; Seda, Vaclav; Zeni, Pedro Faria; Borsky, Marek; Matulova, Kvetoslava; Kren, Leos; Oppelt, Jan; Blavet, Nicolas; Hejret, Vaclav; Urik, Milan; Mareckova, Andrea; Rimsza, Lisa M; Kamaradova, Katerina; Belada, David; Sykorova, Alice; Mocikova, Heidi; Trneny, Marek; Prouzova, Zuzana; Evans, Andrew G; Danilov, Alexey; Horn, Heike; Ott, German; Staber, Philipp; Mayer, Jiri; Friedberg, Jonathan W; Janikova, Andrea; Mraz, Marek
T细胞
信号转导
淋巴瘤
CD40
MYC
CD4
发表日期：2026
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Engineered CD40-biosensor-expressing Treg cells as a cell therapy approach for inflammatory diseases

工程化表达CD40生物传感器的Treg细胞作为炎症性疾病的细胞治疗方法

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2026.01.002
Bittner, Sebastian; Schmidleithner, Lisa; Ruhland, Brigitte; Hofmann, Veronika; Stüve, Philipp; Hoffmann, Frauke; Echtenacher, Bernd; Hoffmann, Petra; Edinger, Matthias; Beilhack, Andreas; Strieder, Nicholas; Hernandez-Lopez, Inmaculada; Rehli, Michael; Hehlgans, Thomas; Feuerer, Markus
炎症/感染
Treg
细胞生物学
CD4
CD40
炎症
T细胞
发表日期：2026
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A CD40-OX40 co-stimulatory circuit orchestrates protective CD4(+) T cell immunity in tuberculosis

CD40-OX40共刺激回路在结核病中协调保护性CD4(+) T细胞免疫

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.12.062
Zhang, Ximeng; Yang, Jing; Li, Fuxiang; Wang, Yu; Li, Zhaodong; Wang, Wenfei; Hu, Yunlong; Shi, Chenyan; Pan, Fan; Feng, Carl G; Wang, Yejun; Yang, Qianting; Chen, Xinchun; Cai, Yi
T细胞
CD40
T细胞
细胞生物学
CD4
免疫/内分泌
发表日期：2026
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Systolic pressure overload caused pulmonary oxidative stress, vessel remodeling and severe microvascular thrombosis in CD40 knockout mice through promoting platelet aggregation

收缩压过高通过促进血小板聚集，导致CD40基因敲除小鼠肺部氧化应激、血管重塑和严重的微血管血栓形成。

期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2026.104122
Yue, Wenhui; Xu, Yanyan; Weng, Xinyu; Wang, Dongzhi; Shang, Linlin; Jiang, Haojie; Weir, Edward Kenneth; Liu, Junling; Xu, Yawei; Che, Wenliang; Chen, Yingjie
T细胞
毒理研究
CD4
CD40
氧化应激
心血管
血小板
发表日期：2026
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CD79A/CD40 intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis

CD79A/CD40胞内结构域利用由胆固醇生物合成驱动的4-1BB样代谢途径

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2025-012309
Takeuchi, Yuki; Terakura, Seitaro; Ishigiwa, Kohei; Julamanee, Jakrawadee; Hirano, Shiho; Yokota, Hirofumi; Kuwano, Shihomi; Hanajiri, Ryo; Kiyoi, Hitoshi
CD7
T细胞
CD40
代谢
CD79A
CD4
发表日期：2026
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Phase I/II clinical trial of a melanoma vaccine targeting shared non-mutated antigens and a shared mutated BRAF neoantigen with an agonistic CD40 antibody (CDX-1140) plus TLR3 agonist (poly-ICLC)

针对共同的非突变抗原和共同的突变BRAF新抗原的黑色素瘤疫苗的I/II期临床试验，采用激动性CD40抗体（CDX-1140）和TLR3激动剂（poly-ICLC）

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2025-013613
Ninmer, Emily K; Petroni, Gina R; Gastman, Brian R; Gaughan, Elizabeth M; Isaacs, James M; Haden, Kathleen; Kaur, Varinder; Wages, Nolan A; Chianese-Bullock, Kimberly A; Smith, Kelly T; Wright, Paul; Bryant, Jennifer; Dunlap-Brown, Marya; Engel, Jack A; Bekiranov, Stefan; Mauldin, Ileana S; Truong, Thach-Giao; Bullock, Timothy N J; Slingluff, Craig L Jr
黑色素瘤
T细胞
BRAF
CD40
CLC
CD4
发表日期：2026
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CAR-T triggers TAM reeducation and adaptive anti-tumor response via TREM2 deficiency or CD40 agonist.

CAR-T 通过 TREM2 缺陷或 CD40 激动剂触发 TAM 再教育和适应性抗肿瘤反应。

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2025.102539
Liu Ting, Gao Huixin, Xi Zhihui, Yu TianTian, Gu Yimei, Mai Hanbing, Yuan Hui, Liu Yafang, Liu Haikuan, Zhang Qiaoxuan, Huang Xianzhang, Fan Wenzhe, Tan Jizhou
肿瘤
T细胞
肿瘤免疫
TREM2
CD40
CD4
发表日期：2026
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CD40 drives tumor growth in non-small cell lung cancer via non-canonical immune-independent mechanisms.

CD40 通过非经典免疫非依赖性机制驱动非小细胞肺癌的肿瘤生长。

期刊:Cancer Letters
影响因子:10.1
doi:10.1016/j.canlet.2025.218151
Liu Yujie, Prasad Chandra Bhushan, Qiu Zhaojun, Singh Deepika, Bean Nicholas, Honne Shravya, Zhang Xiaoli, Yan Chunhong, Li Zaibo, Kim Baek, Wang Qi-En, Zhang Junran
肺癌
细胞生物学
T细胞
CD4
CD40
发表日期：2026
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Reduced tumor control in males can result from impaired CD4+ T-cell help through the CD40L-CD40 pathway

男性肿瘤控制能力下降可能是由于CD4+ T细胞通过CD40L-CD40通路发挥辅助作用受损所致。

期刊:Cancer Immunology Research
影响因子:8.2
doi:10.1158/2326-6066.CIR-25-1115
Hunt, Katey S; Cooke, Samantha; Kuehm, Lindsey M; Lobb, Tyson A; Ebert, Emily; Beeram, Smrithi; Teague, Ryan M; Brennan, Michelle; Berrien-Elliott, Melissa M; Ferris, Stephen T; Alspach, Elise
信号转导
免疫/内分泌
细胞生物学
CD4
T细胞
CD40
肿瘤
肿瘤免疫
T细胞
发表日期：2026
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