日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting CDK12/13 Drives Mitotic Arrest to Overcome Resistance to KRASG12C Inhibitors

靶向 CDK12/13 可诱导有丝分裂停滞,从而克服对 KRASG12C 抑制剂的耐药性

Stern, Yaakov E; Ghosh, Pompom; Peroza, John; Solanki, Hitendra S; Imbody, Denis; Bridenstine, Liznair; Pandurangan, Thiyagamurthy; Frydman, Sylvia M; Nickens, Kathryn N; Walker-Mimms, Hannah L; Suvarna, Kruthi; Chaudhary, Neelkamal; Monastyrskyi, Andrii; Duckett, Derek; Haura, Eric B

RE: Targeting CDK12 disrupts estrogen-receptor chromatin recruitment and ER-MED1 transcription in advanced ER+ breast cancer

回复:靶向 CDK12 可破坏晚期 ER+ 乳腺癌中雌激素受体染色质募集和 ER-MED1 转录

Lehrer, Steven

Targeting CDK12 disrupts estrogen-receptor chromatin recruitment and ER-MED1 transcription in advanced ER+ breast cancer

靶向 CDK12 会破坏晚期 ER+ 乳腺癌中雌激素受体染色质募集和 ER-MED1 转录

Ottaviani, Daniela; Ola, Mihaela; Allotta, Alessandra; Maati Chaibi, Yasmine; Hickey, Seán; Jagust, Petra; Cosgrove, Nicola; Cocchiglia, Sinéad; Bane, Fiona; Fallon, Ramón; Daly, Gordon; Hegarty, Aisling; Hudson, Lance; Sheehan, Katherine; Kalsi, Shannon; Shovlin, Stephen; Powell, Aoibhín; Bahl, Ash; Ainscow, Ed; Oesterreich, Steffi; Lee, Adrian V; Couch, Fergus J; Hill, Arnold D K; Varešlija, Damir; Young, Leonie

CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3-Mediated Mitophagy

CDK12失活通过抑制BNIP3介导的线粒体自噬来减缓前列腺癌的进展

Huang, Mengjun; Lei, Hanqi; Tong, Tongyu; Zou, Hailin; Yan, Binyuan; Cao, Fei; Wang, Yiting; Teng, Qiliang; Xu, Bin; Luo, Juan; Guan, Yupeng; Lai, Shaohong; Li, Peng; Pang, Jun

CDK12 and CDK13 in oncology: from RNA regulation to therapeutic targeting

CDK12 和 CDK13 在肿瘤学中的作用:从 RNA 调控到治疗靶向

Dudkiewicz-Garbicz, Julia; Włodarski, Paweł K

Penile metastasis from prostate cancer with CDK12 mutation: A case report and literature review

CDK12突变型前列腺癌阴茎转移:病例报告及文献综述

Xiang, Qi; Wang, Yanwu; Yao, Bin; Tang, Huiwen; Dang, Qiang

Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders

CDK12/13 和 BRD4 分子胶降解剂的合理设计

Zhuang, Zhe; Byun, Woong Sub; Kozicka, Zuzanna; Donovan, Katherine A; Dwyer, Brendan G; Thornhill, Abby M; Jones, Hannah M; Jiang, Zixuan; Zhu, Xijun; Fischer, Eric S; Thomä, Nicolas H; Gray, Nathanael S

Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system

转录激酶CDK12和CDK13在中枢神经系统中的生理和病理作用

Pitolli, Consuelo; Marini, Alberto; Sette, Claudio; Pagliarini, Vittoria

DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers

DNA2蛋白的破坏决定了CDK12失调癌症中的DNA过度切除、cGAS-STING激活和先天免疫反应。

Sun, Rui; Jiang, Peng; Wang, Zhijun; Yan, Binyuan; Zhu, Shouhai; Huang, Zhenlin; Zhang, Jianong; Ding, Donglin; Li, Xiang; Wang, Liguo; Lou, Zhenkun; Jin, Baiye; Pang, Jun; Huang, Haojie; Xia, Dan

Correction for Sun et al., DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers

对 Sun 等人的论文《DNA2 蛋白破坏决定 CDK12 失调癌症中的 DNA 过度切除、cGAS-STING 激活和先天免疫反应》的更正