日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

CDK2抑制剂BLU-222通过诱导p21/p27与CDK4/6抑制剂协同作用,治疗耐药性乳腺癌。

Luo, Linjie; Wang, Yan; Bui, Tuyen; Jiang, Xiaoting; Chen, Mei-Kuang; Rao, Xiayu; Mohammadhosseinpour, Sepideh; Li, Mi; Kim, Serena; Kim, Rachel Y; Kamaliasl, Saba; Ulizio, Carmen W; Tsavachidis, Spyros; Navarro-Yepes, Juliana; Kettner, Nicole M; Wingate, Hannah; Meric-Bernstam, Funda; Hunt, Kelly K; Wang, Jing; Faia, Kerrie; Keyomarsi, Khandan

Advances in molecular glue degraders for targeted protein degradation: Focus on NEK7, WEE1, CDK2, GSPT1 and VAV1

用于靶向蛋白质降解的分子胶降解剂的研究进展:重点关注 NEK7、WEE1、CDK2、GSPT1 和 VAV1

Cheng, Binbin; Wang, Yaping; Hong, Yimeng; Zhou, Yingxing; Peng, Xiaopeng; Chen, Jianjun; Zeng, Chunlai

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

鱼类 CDK2 招募 Dtx4,通过泛素化作用降解 TBK1,从而参与抗病毒反应。

Lu, Long-Feng; Zhang, Can; Li, Zhuo-Cong; Cui, Bao-Jie; Wang, Yang-Yang; Han, Ke-Jia; Xu, Xiao; Zhou, Chu-Jing; Zhou, Xiao-Yu; Wu, Yue; Xu, Na; Yang, Xiao-Li; Chen, Dan-Dan; Li, Xiyin; Zhou, Li; Li, Shun

LncRNA H19-Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

lncRNA H19编码的微肽altH19通过增强CDK2在苏氨酸160位点的磷酸化来促进骨髓瘤细胞的DNA复制和有丝分裂。

Zhang, Yaxin; Li, Wenjing; Cao, Xu; Mao, Jiwei; Zhou, Xiaodan; Liu, Linlin; Yao, Ruosi

Malva sylvestris Flower Extract Exhibits Antineoplastic Potential Against Human Colon Cancer Cell Lines and Induces CDK2 Transcript Instability via Plant miR160-5p

锦葵花提取物对人结肠癌细胞系表现出抗肿瘤活性,并通过植物 miR160-5p 诱导 CDK2 转录本不稳定。

Villani, Valentina; Gismondi, Angelo

Design and Evaluation of New 6-Trifluoromethoxy-Isatin Derivatives as Potential CDK2 Inhibitors

新型6-三氟甲氧基靛红衍生物作为潜在CDK2抑制剂的设计与评价

Czeleń, Przemysław; Szefler, Beata

Phase I/II Study of the CDK2/9 Inhibitor Fadraciclib in Combination with Chemotherapy in Children with Advanced Malignancies: Arm K of the AcSé-ESMART Trial

CDK2/9抑制剂Fadraciclib联合化疗治疗晚期恶性肿瘤患儿的I/II期研究:AcSé-ESMART试验的K组

Rubio-San-Simón, Alba; Marshall, Lynley V; Karamouza, Eleni; André, Nicolas; Abbou, Samuel; Rubino, Jonathan; Nebchi, Souad; Aerts, Isabelle; Thebaud, Estelle; Brisset, Claire; Ducassou, Stephane; Le Teuff, Gwénaël; Geoerger, Birgit

Integrated DFT, molecular docking, and molecular dynamics investigation of some novel 2-thiohydantoin analogues as potent CDK2 inhibitors for anticancer therapy

综合运用密度泛函理论、分子对接和分子动力学方法,研究一些新型2-硫代乙内酰脲类似物作为强效CDK2抑制剂在抗癌治疗中的应用

Khaled, Nada A; Ahmed, Sayed A; Ibrahim, Medhat A; Ahmed, Osama M; Mohamed, Neama A; Khalifa, Nagy M

CDK2 inhibition promotes neuronal differentiation in neuroblastoma.

CDK2抑制促进神经母细胞瘤中的神经元分化。

Alzrigat Mohammad, Mahmoud Loay, Topçu Ada Nursel, Valenti Marta, Zhang Lu, Veen Puck, John Fabian, Bazzar Wesam, Lehti Kaisa, Larsson Lars-Gunnar

Gramine Suppresses Cervical Cancer by Targeting CDK2: Integrated Omics-Pharmacology and In Vitro Evidence

革兰氏染色通过靶向 CDK2 抑制宫颈癌:整合组学-药理学和体外证据

Zhou, Zhiyan; Li, Jin; Zhao, Xingji; Xu, Hongxia; Xiao, Yu; Wang, Hongchen; Chen, Ying