CHKA相关文献与解析，生知库 | 链接生命科学的每一步

Wang, Ruijie; Cao, Leixi; He, Xianwei; Thorne, Rick Francis; Wu, Qichen; Ding, Caoyuan; Zhang, Jinjing; Li, Mengfan; Shi, Zeyuan; Dong, Xinyi; Li, Jing; Li, Hongxiang; Gao, Suhua; Li, Jinming; Zhang, Xu Dong; Jin, Lei; Fan, Tianli; Wu, Mian

自噬

CHKA

PML

The KANSL1-ARL17A fusion gene generates oncogenic chKANSARL and F-circKA RNAs that synergistically drive lung cancer progression via a novel F-circKA/miR-6860/chKANSARL axis.

KANSL1-ARL17A 融合基因产生致癌的 chKANSARL 和 F-circKA RNA，通过新的 F-circKA/miR-6860/chKANSARL 轴协同驱动肺癌进展。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2026.111170

Guan Xinchao, Liu Tao, Chen Sili, Zhang Junwei, Huang Huanliang, Chen Dexiong, Yang Qiaoyuan

Neurodevelopmental disease-causing variants in choline kinase CHKA gene couple phosphatidylcholine synthesis to oxidative stress damage and disease etiology.

胆碱激酶 CHKA 基因的神经发育疾病致病变异将磷脂酰胆碱合成与氧化应激损伤和疾病病因联系起来。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.110983

Tavasoli Mahtab, Alkandari Mariam, Dorighello Gabriel, McPhee Michael, Ridgway Neale D, Isaac Kathy, Sokolenko Stanislav, Maroofian Reza, Shukla Anju, Zaki Maha S, Houlden Henry, McMaster Christopher R

Metabolic Stress-Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes-Associated Microvascular Dysfunction

代谢应激诱导的内皮细胞亚群中胆碱激酶α (CHKA) 激活导致糖尿病相关微血管功能障碍

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202417045

Ren, Ling; Zhang, Linyu; Bai, Yun; Huang, Chang; Li, Xiaosa; Ma, Fanfei; Mu, Wan; Yao, Mudi; Jiang, Chang; Chen, Xiangjun; Jiang, Qin; Yan, Biao

Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect

氯喹通过靶向CHKA和PFKM抑制PI3K/AKT通路和瓦博格效应，从而抑制结直肠癌进展。

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.101921

Liu, Yanqing; Zhu, Yongping; Gu, Liwei; Li, Kexin; Ma, Ang; Liu, Li; Meng, Yuqing; Zhang, Junzhe; Shen, Shengnan; Shi, Qiaoli; Liu, Dandan; Zhang, Xinwei; Zhang, Shujie; Chai, Xin; Gao, Peng; Xing, Jiale; Wang, Yaxu; Chen, Honglin; Liu, Rui; Du, Qingfeng; Liu, Haitao; Dai, Lingyun; Wang, Jigang

Protocol for the creation and utilization of 3D pancreatic cancer models from circulating tumor cells

利用循环肿瘤细胞构建和应用3D胰腺癌模型的方案

期刊:STAR Protocols

影响因子:1.3

doi:10.1016/j.xpro.2025.103635

Jiajia Tang ,Quan Zheng ,Qi Wang ,Yaru Zhao ,Preeta Ananthanarayanan ,Chiara Reina ,Berina Šabanović ,Ke Jiang ,Ming-Hsin Yang ,Clara Csilla Meny ,Huimin Wang ,Mette Ø Agerbaek ,Thomas Mandel Clausen ,Tobias Gustavsson ,Chenlei Wen ,Felice Borghi ,Alfredo Mellano ,Elisabetta Fenocchio ,Vanesa Gregorc ,Anna Sapino ,Thor G Theander ,Da Fu ,Alexandra Aicher ,Ali Salanti ,Baiyong Shen ,Christopher Heeschen

A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

靶向性 III 型免疫反应伴 IL-17A 表达 CD4+ T 细胞增加与黑色素瘤免疫疗法引起的毒性相关。

期刊:Nature Cancer

影响因子:23.5

doi:10.1038/s43018-024-00810-4

Florentia Dimitriou ，Phil F Cheng ，Annalisa Saltari ，Katrin Schaper-Gerhardt ，Ramon Staeger ，Veronika Haunerdinger ，Federica Sella ，Aizhan Tastanova ，Christian Urban ，Susanne Dettwiler ，Daniela Mihic-Probst ，Christian M Matter ，Olivier Michielin ，Ralf Gutzmer ，Georgina V Long ，Burkhard Becher ，Mitchell P Levesque # ，Reinhard Dummer #

Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

IL-6 N-糖基化缺陷可诱导肺癌转移和酪氨酸激酶抑制剂耐药性

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-51831-7

Chun-Hua Hung ,Shang-Yin Wu ,Cheng-I Daniel Yao ,Hsuan-Heng Yeh ,Chien-Chung Lin ,Chang-Yao Chu ,Tzu-Yu Huang ,Meng-Ru Shen ,Chun-Hung Lin ,Wu-Chou Su

Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling

柯萨奇病毒A10通过模拟DKK1减弱Wnt信号传导，从而损害指甲再生并诱导甲剥离。

期刊:Journal of Experimental Medicine

影响因子:12.6

doi:10.1084/jem.20231512

Yingzi Cui #,Qiaoni Shi #,Pu Song,Jianyu Tong,Zhimin Cheng,Hangchuan Zhang,Xiaodan Wang,Yuxuan Zheng,Yao Wu,Meng Wan,Shihua Li,Xin Zhao,Zhou Tong,Zhengquan Yu,Shan Gao,Ye-Guang Chen,George Fu Gao

CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches

CTC衍生的胰腺癌模型可作为研究工具，适用于精准医疗方法。

期刊:Cell Reports Medicine

影响因子:11.7

doi:10.1016/j.xcrm.2024.101692

A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation

CHKA-PML自噬检查点使肿瘤能够逃避谷氨酰胺饥饿

The KANSL1-ARL17A fusion gene generates oncogenic chKANSARL and F-circKA RNAs that synergistically drive lung cancer progression via a novel F-circKA/miR-6860/chKANSARL axis.

KANSL1-ARL17A 融合基因产生致癌的 chKANSARL 和 F-circKA RNA，通过新的 F-circKA/miR-6860/chKANSARL 轴协同驱动肺癌进展。

Neurodevelopmental disease-causing variants in choline kinase CHKA gene couple phosphatidylcholine synthesis to oxidative stress damage and disease etiology.

胆碱激酶 CHKA 基因的神经发育疾病致病变异将磷脂酰胆碱合成与氧化应激损伤和疾病病因联系起来。

Metabolic Stress-Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes-Associated Microvascular Dysfunction

代谢应激诱导的内皮细胞亚群中胆碱激酶α (CHKA) 激活导致糖尿病相关微血管功能障碍

Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect

氯喹通过靶向CHKA和PFKM抑制PI3K/AKT通路和瓦博格效应，从而抑制结直肠癌进展。

Protocol for the creation and utilization of 3D pancreatic cancer models from circulating tumor cells

利用循环肿瘤细胞构建和应用3D胰腺癌模型的方案

A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

靶向性 III 型免疫反应伴 IL-17A 表达 CD4+ T 细胞增加与黑色素瘤免疫疗法引起的毒性相关。

Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

IL-6 N-糖基化缺陷可诱导肺癌转移和酪氨酸激酶抑制剂耐药性

Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling

柯萨奇病毒A10通过模拟DKK1减弱Wnt信号传导，从而损害指甲再生并诱导甲剥离。

CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches

CTC衍生的胰腺癌模型可作为研究工具，适用于精准医疗方法。