Anti-p53 antibody [E26] (Ab32389)

P53, TP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

反应种属:Human
抗原名称:TP53
应用:WB, IHC, FCM, IF/ICC, IP, CUT&RUN-seq

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

The antibody should recognize human wild-type and mutant p53.

背景信息

What is this antibody validated in? Anti-p53 antibody [E26] (ab32389) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of p53? Anti-p53 [E26] (ab32389) specifically detects a band for p53 (UniProt: P04637) at a molecular weight of 44kDa. Trusted by the scientific community Anti-p53 [E26] (ab32389) was first used in a scientific publication in 2006 and has been cited over 110 times in peer-reviewed journals. Specificity confirmed The specificity of Anti-p53 antibody [E26] (ab32389) has been confirmed by Western blot testing in TP53 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [E26] also available for your convenience: ab32389, Alexa Fluor ® 647 - ab224942, Alexa Fluor ® 488 - ab224943, Carrier free - ab225531, APC - ab310855, PE - ab310924, Alexa Fluor ® 594 - ab311727, Alexa Fluor ® 568 - ab313004, Alexa Fluor ® 555 - ab313208, Alexa Fluor ® 750 - ab321599 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies.

文献引用 (135)

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Ongoing genome doubling shapes evolvability and immunity in ovarian cancer.

持续的基因组倍增塑造了卵巢癌的进化能力和免疫力

McPherson Andrew, Vázquez-García Ignacio, Myers Matthew A, Al-Rawi Duaa H, Zatzman Matthew, Weiner Adam C, Freeman Samuel, Mohibullah Neeman, Satas Gryte, Williams Marc J, Ceglia Nicholas, Norkūnaitė Danguolė, Zhang Allen W, Li Jun, Lim Jamie L P, Wu Michelle, Choi Seongmin, Havasov Eliyahu, Grewal Diljot, Shi Hongyu, Kim Minsoo, Schwarz Roland F, Kaufmann Tom, Dinh Khanh Ngoc, Uhlitz Florian, Tran Julie, Wu Yushi, Patel Ruchi, Ramakrishnan Satish, Kim DooA, Clarke Justin, Green Hunter, Ali Emily, DiBona Melody, Varice Nancy, Kundra Ritika, Broach Vance, Gardner Ginger J, Roche Kara Long, Sonoda Yukio, Zivanovic Oliver, Kim Sarah H, Grisham Rachel N, Liu Ying L, Viale Agnes, Rusk Nicole, Lakhman Yulia, Ellenson Lora H, Tavaré Simon, Aparicio Samuel, Chi Dennis S, Aghajanian Carol, Abu-Rustum Nadeem R, Friedman Claire F, Zamarin Dmitriy, Weigelt Britta, Bakhoum Samuel F, Shah Sohrab P

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Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation

谷胱甘肽还原酶通过拮抗蛋白质谷胱甘肽化来维持突变 p53 的稳定性

Liansheng Wang, Suqin Zhong, Xinru Fan, Yuxue Xu, Meimei Wang, Youcui Xu, Yuanyuan Cai, Zhong Cao, Zhiming Ye, Longping Wen, Pengfei Wei

LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling.

LINE1 插入 NACC2 位点会破坏 HDM2 轴并激活肺致癌信号

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Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stress.

靶向 ESR1 可恢复 SQSTM1 依赖性自噬,并使 ER 阳性乳腺癌对氧化应激和辐射应激更加敏感。

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Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization.

LXN/Rps3/p53 信号通路激活促进的肾上皮细胞过早衰老通过改变巨噬细胞极化增加草酸钙晶体沉积。

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