Anti-SIRT1 antibody [E104] (Ab32441)

SIR2L1, SIRT1, NAD-dependent protein deacetylase sirtuin-1, hSIRT1, NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2

反应种属:Human
抗原名称:SIRT1
应用:WB, IHC, FCM, IF/ICC, IP

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

This antibody does not cross-react with other sirtuin family members. Expression levels of the target protein vary with sample type and some optimisation may be required. For western blotting, more concentrated lysates may be required when using tissues samples.

背景信息

What is this antibody validated in? Anti-SIRT1 antibody [E104] (ab32441) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of SIRT1? Anti-SIRT1 [E104] (ab32441) specifically detects a band for SIRT1 (UniProt: Q96EB6) at a molecular weight of 82kDa. Trusted by the scientific community Anti-SIRT1 [E104] (ab32441) was first used in a scientific publication in 2006 and has been cited over 150 times in peer-reviewed journals. Reviewed by scientists Anti-SIRT1 [E104] (ab32441) has over 10 independent reviews from customers. Specificity confirmed The specificity of Anti-SIRT1 antibody [E104] (ab32441) has been confirmed by Western blot testing in SIRT1 Knockout HEK-293 cell line. Other related products We have a range of other formats of antibody clone [E104] also available for your convenience: ab32441, Alexa Fluor® 647 - ab196144, Alexa Fluor® 488 - ab196368, Carrier free - ab220807, PE - ab303068, APC - ab303069, HRP - ab303070, Alkaline Phosphatase - ab308936, Alexa Fluor® 594 - ab310692, Alexa Fluor® 555 - ab312222, Alexa Fluor® 568 - ab312711, Alexa Fluor® 750 - ab321603 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies.

文献引用 (125)

Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles Reverse Endothelial-Mesenchymal Transition in Atherosclerosis.

工程化间充质干细胞衍生的细胞外囊泡逆转动脉粥样硬化中的内皮-间质转化

Chen Zhuo, Chang Kai, Yang Sha, Deng Ruijia, He Yuan, Zhang Ligai, Chen Ming, Bai Dingqun, Pi Yan

Hypoxia-Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis.

缺氧诱导的 PRMT1 乳酸化驱动肿瘤转移中的波形蛋白精氨酸不对称二甲基化。

Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.

靶向IGF1诱导的细胞衰老以延缓毛囊衰老

Wang Yang, Yang Jian, Luo Yue, Zhao Zhiqiang, Yuan Yawen, Li Juan, Liu Yang, Yi Yong, Xu Xiaoke, Lan Yuankunyu, Zou Juan, Li Qintong, Wang Liang, Pan Yang, Yang Yuanhan, Xiong Muzhao, Wu Min, Li Jinsong, Li Weiyuxin, Zhang Yujun, Cao Yang, Zhu Yi, Xiao Zhi-Xiong Jim

Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis, leading to rotenone-induced G2/M arrest.

微管蛋白过度乙酰化通过 ROS-PARP1 轴驱动 HMGB1 核外移出,导致鱼藤酮诱导的 G2/M 期阻滞。

Dutta Sourav, Chakraborty Semanti, Ghosh Ayushi, Halder Priyadarshini, Majumder Shubhra, Paul Ratnadip, Nath Somsubhra, Mukherjee Piyali

Nicotinic acid protects germinal vesicle oocyte meiosis against toxicity of benzo(a)pyrene in mice and humans.

烟酸可保护小鼠和人类的生殖泡卵母细胞减数分裂免受苯并[a]芘的毒性作用

Gao Min, Qiu Yanling, Li Dungao, Zhan Shaoquan, Chen Bohong, Cao Tianqi, Huang Junjiu, Chen Zhiyun

USP28 participates in high glucose-mediated endothelial dysfunction via deubiquitinating SIRT1 protein in diabetic foot ulcers.

USP28 通过去泛素化 SIRT1 蛋白参与糖尿病足溃疡中高葡萄糖介导的内皮功能障碍。

Liu Qiong, Zhang Jin, Bai Jichang, Liu Kuanzhi

Magnesium isoglycyrrhizinate prevented the liver injury of acetaminophen by promoting mitochondrial biogenesis.

异甘草酸镁通过促进线粒体生物合成来预防对乙酰氨基酚引起的肝损伤

Xia Shuang, Hu Zhi-Yu, Cao Rong, Guo Lin, Ma Jia-Ting, Xiao Ming-Xuan, Liu Jiayi, Zhai Bo-Wen, Fu Rao, Jiang Zhi-Chao, Gong Hui, Yan Miao

Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis

通过靶向 SIRT1-HIF-2α 轴解除软骨肉瘤中 NAD+ 代谢依赖性

Jooyeon Suh,Hyeonkyeong Kim,Jiyun Min,Hyun Ju Yeon,Martin Hemberg,Luca Scimeca,Ming-Ru Wu,Hyun Guy Kang,Yi-Jun Kim,Jin-Hong Kim

NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner

NCAPD3 以 H3K9 单甲基化依赖的方式调节 SIRT1 表达,促进弥漫大 B 细胞淋巴瘤进展

Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

AROS 激活的 SIRT1 通过诱导 NAD+ 耗竭依赖性的 ATF3 激活,使胶质瘤细胞对铁死亡敏感

Xi Chen, Zhenchuan Wang, Chen Li, Zhao Zhang, Shan Lu, Xuanzhong Wang, Qi Liang, Xiaoxi Zhu, Chengliang Pan, Qingxuan Wang, Zhilin Ji, Yubo Wang, Meihua Piao, Guangfan Chi, Pengfei Ge
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 13