Anti-Cleaved PARP1 antibody [E51] (Ab32064)

ADPRT, PPOL, PARP1, Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose] synthase 1, Protein poly-ADP-ribosyltransferase PARP1, ARTD1, ADPRT 1

反应种属:Human, Mouse, Rat
抗原名称:PARP1
应用:WB, IHC

用户验证的应用

推荐稀释比例

  • IHC-P1/100 Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
  • WB1/1000 - 1/10000

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-Cleaved PARP1 antibody [E51]
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
纯化方式Affinity purification Protein A

背景信息

What is this antibody validated in? Anti-Cleaved PARP1 antibody [E51] (ab32064) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples. What is the molecular weight of Cleaved PARP1? Anti-Cleaved PARP1 [E51] (ab32064) specifically detects a band for Cleaved PARP1 (UniProt: P09874) at a molecular weight of 25kDa. Trusted by the scientific community Anti-Cleaved PARP1 [E51] (ab32064) was first used in a scientific publication in 2006 and has been cited over 400 times in peer-reviewed journals. Reviewed by scientists Anti-Cleaved PARP1 [E51] (ab32064) has over 15 independent reviews from customers. Specificity confirmed The specificity of Anti-Cleaved PARP1 antibody [E51] (ab32064) has been confirmed by Western blot testing in PARP1 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [E51] also available for your convenience: ab32064, Carrier free - ab203467 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies.

文献引用 (456)

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

肝脏分区决定突变β-catenin的致瘤潜力。

Raven Alexander, Gilroy Kathryn, Jin Hu, Waldron Joseph A, Leslie Holly, Munro June, Hall Holly, Ridgway Rachel A, Ford Catriona A, Gulhan Doga C, Vlahov Nikola, Mills Megan L, Hartley Andrew, Anderson Eve, Bryson Sheila, Sphyris Nathalie, Müller Miryam, May Stephanie, Cadden Barbara, Nixon Colin, Waddell Scott H, Guest Rachel, Boulter Luke, Barker Nick, Clevers Hans, Zhu Hao, Ivaska Johanna, Strathdee Douglas, Miller Crispin J, Jamieson Nigel B, Bushell Martin, Park Peter J, Bird Thomas G, Sansom Owen J

SOX2 confers tumour permissiveness in a specific skin progenitor population.

SOX2 赋予特定皮肤祖细胞群肿瘤易感性。

Centeno Patricia P, Chester Christopher, Kanellos Georgios, Ford Catriona A, Cammareri Patrizia, Inman Gareth J, Jamieson Thomas, Ridgway Rachel A, Marais Richard, Campbell Andrew D, Sansom Owen J

The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.

脑成像特征相关基因 NRP2 通过 FAK 通路驱动胶质母细胞瘤的恶性进展:一项孟德尔随机化研究。

Li Yang, Que Jun, Xia Yong, Wang Lei, Zhang Pinshan, Cheng Zhen, Gao Bo

PLAGL1 overexpression exacerbates type 1 diabetes by inducing β-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation.

PLAGL1 过表达通过氧化应激依赖的双重 DNA 损伤和 cGAS/STING 通路激活诱导 β 细胞凋亡,从而加剧 1 型糖尿病。

Li Cheng, Qiao Lingyan, Ge Juan, Hu Sicui, Yang Hongxiu, Hu Conghui, Li Tang

Oleanolic acid-chitosan compound inhibits mitochondrial autophagy and malignant transformation of lung cancer through the PTEN/AKT pathway.

齐墩果酸-壳聚糖化合物通过 PTEN/AKT 通路抑制线粒体自噬和肺癌的恶性转化。

Abulaiti Abulimiti, Sun XiaoHong, Yibulayin Waresijiang, He Dan, Xu KeMing, Yibulayin Xiayimaierdan

Focused Ultrasound Thermal Ablation and CD40 Agonism Reprograms Breast Tumor Immunity to Drive Regression and Memory.

聚焦超声热消融和 CD40 激动剂重编程乳腺肿瘤免疫以驱动消退和记忆。

Demir Zehra E F, Kim AeRyon, Ak Beyzanur G, Lee Micaiah S J, Sherlock Thomas, Maslova Stefanyda O, Thede Andrew T, DeWitt Matthew R, Rutkowski Melanie R, Sheybani Natasha D

Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.

酸性神经酰胺酶抑制会破坏神经酰胺稳态,并诱导 IDH1 突变型少突胶质细胞瘤中的线粒体凋亡。

Larion Mioara, Muley Helena, Zaibaq Faris, Zhang Meili, Davis Dionne, Kruhlak Michael, Mathur Samarth, Lita Adrian, Song Hua, Zhang Wei, Wong Zalman, Harmon Taylor, Zhang Lumin, Cam-El Makranz Chen, Li Aiguo, Karadimov George, Lang Fengchao, Herold-Mende Christel, Yang Chunzhang, Dowdy Tyrone

Systematic identification of Y-chromosome gene functions in mouse spermatogenesis

系统鉴定 Y 染色体基因在小鼠精子发生中的作用

Jeremie Subrini, Wazeer Varsally, Irina Balaguer Balsells, Maike Bensberg, Georgios Sioutas, Obah Ojarikre, Valdone Maciulyte, Björn Gylemo, Katharine Crawley, Katherine Courtis, Dirk G de Rooij, James M A Turner

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy.

化疗期间,caspase-3 对 CAD 的切割决定了癌细胞的命运

Ma Jingsong, Zhao Jiabao, Zhang Chensong, Tan Jinshui, Cheng Ao, Niu Zhuo, Lin Zeyang, Pan Guangchao, Chen Chao, Ding Yang, Zhong Mengya, Zhuang Yifan, Xiong Yubo, Zhou Huiwen, Zhou Shengyi, Xu Meijuan, Ye Wenjie, Li Funan, Song Yongxi, Wang Zhenning, Hong Xuehui

Aging-rewired metabolic cues promote autophagy and senescence via DRAM1.

衰老重塑的代谢信号通过 DRAM1 促进自噬和衰老。

Yang Jinghong, Sun Haobin, Xu Keqing, Zhang Xiaomei, Huang Mudan, Jin Guanghui, Liu Yasong, Chen Weizhao, Lin Shunan, Shen Juan, Zhong Chuan-Qi, Xu Yan, Zhang Qi, Liu Wei, Yang Yang, Ou Jingxing
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