Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (Ab51253)

特异性

This antibody only detects alpha synuclein phosphorylated on Ser129. IHC-P: This antibody showed no staining in human hippocampus normal brain and showed staining in Parkinson's brain as expected. Mouse and rat species are recommended based on WB results, we do not guarantee  IHC-P for mouse and rat.

Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, ELISA, IHC-FrFl, IHC-P, WB in human, mouse, rat samples. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) has been cited over 373 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Alpha-synuclein (phospho S129) antibody (Anti-pS129 alpha synuclin antibody/ Anti-SNCA antibody) [EP1536Y] (ab51253) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) has 9 independent reviews from customers. Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (ab51253) specifically detects Alpha-synuclein Phospho-S129 (UniProt ID: P37840; Molecular weight: 14kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1536Y - ab209422. Antibody clone EP1536Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 750, PE, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 568 ( ab321645, ab314419, ab225294, ab225295, ab311788, ab313069 ). Alpha-synuclein phosphorylated at serine 129 (pS129; phosphorylated alpha synuclein, SNCA/NACP) is a modified form of the alpha-synuclein protein, which plays a crucial role in the regulation of synaptic vesicle trafficking and neurotransmitter release. This phosphorylation is significantly increased in the brains of patients with Parkinson's disease and other synucleinopathies. The presence of pS129 is associated with the formation of Lewy bodies, a hallmark of Parkinson's disease, and is believed to contribute to the neurotoxic properties of alpha-synuclein, exacerbating disease progression. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.