Anti-Nrf2 antibody [EP1808Y] (Ab62352)

特异性

The expression of Nrf2 is stimulated by oxidative stress, electrophiles and chemical activators (PMID: 25761198, PMID: 27638861 and PMID: 28587109). Nrf2 antibody (ab62352) detects no signal in most untreated samples in WB. Stimuli treated samples are recommended. We do not recommend using this product in western blot with tissue lysates, however some customers have used this antibody successfully using concentrated samples (see submitted abreviews).

Anti-Nrf2 antibody [EP1808Y] (ab62352) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF and WB. Anti-Nrf2 antibody [EP1808Y] (ab62352) was first used in a scientific publication in 2009 and has been cited over 584 times in peer reviewed journals. It's performance in Western Blot in human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Nrf2 antibody [EP1808Y] (ab62352) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Nrf2 antibody [EP1808Y] (ab62352) has been confirmed by Western Blot testing in Nrf2 knockout HeLa cells ( ab262507 ). Anti-Nrf2 antibody [EP1808Y] (ab62352) has 28 independent reviews from customers. Anti-Nrf2 antibody [EP1808Y] (ab62352) specifically detects Nrf2 (UniProt ID: Q16236; Molecular weight: 68kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1808Y - ab180845. Antibody clone EP1808Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, Alexa Fluor ® 594, PE, APC ( ab194984, ab194985, ab206890, ab223926, ab223927 ). NRF2 is a pivotal transcription factor in neuro research, known for regulating cellular defense mechanisms. It supports mitochondrial function and protects against oxidative damage, which is crucial for brain health. NRF2 also modulates glial inflammatory responses, playing a significant role in preventing neuroinflammation. Researchers use NRF2 to study oxidative stress, inflammation and neuroprotection, making it essential for understanding and potentially treating neurodegenerative diseases. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.