详细信息
特异性
Detects endogenous levels of Synuclein only when phosphorylated at serine 129. Due to 69% sequence homology ab59264 might react with Beta synuclein.
背景信息
What is this antibody validated in? Anti-Alpha-synuclein (phospho S129) antibody (ab59264) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples. Trusted by the scientific community Anti-Alpha-synuclein (phospho S129) (ab59264) was first used in a scientific publication in 2007 and has been cited over 60 times in peer-reviewed journals.
文献引用 (65)
Anti-TLR2 immunotherapy modulates neuron-to-oligodendrocyte propagation of α-synuclein in mouse and human models.
抗 TLR2 免疫疗法可调节小鼠和人类模型中 α-突触核蛋白从神经元到少突胶质细胞的传播。
Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species
脑室周围小胶质细胞对α-突触核蛋白毒性物质的早期反应中，清除能力随年龄增长而逐渐减弱，最终变得脆弱。
Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia.
活化的微胶质细胞外泌体增强α-突触核蛋白的内化，加速路易体痴呆症的神经退行性变。
Degenerative pathologies on cortical biopsy, dopaminergic depletion, and shunt efficacy in iNPH.
正常压力脑积水患者皮质活检中的退行性病变、多巴胺能耗竭和分流疗效。
Fasudil inhibits α-synuclein aggregation through ROCK-inhibition-mediated mechanisms.
法舒地尔通过 ROCK 抑制介导的机制抑制 α-突触核蛋白聚集
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation
基于 SENP2 的 α-突触核蛋白 N 端截断在路易氏病传播中的作用
Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril injected mouse model of Parkinson's disease.
鱼藤酮可加速内源性α-突触核蛋白的扩散，并增强纹状体内注射α-突触核蛋白预成纤维的帕金森病小鼠模型的神经退行性变。
DDOX expands the repertoire of tetracyclines for Parkinson's disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils.
DDOX 通过阻止 α-突触核蛋白预形成原纤维的细胞摄取和细胞内影响，扩展了四环素类药物在帕金森病治疗中的应用范围。
Nuclear Alpha-Synuclein in Parkinson's Disease and the Malignant Transformation in Melanoma
帕金森病中的核 α-突触核蛋白和黑色素瘤中的恶性转化
Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission
血管紧张素 1 型受体激活促进神经元和神经胶质细胞 α-突触核蛋白的聚集和传输
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