Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (Ab4729)
H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, H3FC, HIST1H3C, H3C1, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H3K27ac
详细信息
特异性
From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.
背景信息
Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (ab4729) is a rabbit polyclonal antibody and is validated for use in ChIP, ICC/IF, IHC-P, PepArr and WB. Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (ab4729) was first used in a scientific publication in 1975 and has been cited over 2188 times in peer reviewed journals. It's performance in ChIP and Western Blot in human and mouse samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (ab4729) has high sensitivity and specificity. Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (ab4729) has 85 independent reviews from customers. Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (ab4729) specifically detects Histone H3 Acetyl-K27 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 100 µg selling sizes. Top cited antibody for this target with >2500 citations and 70 five star abreviews. This antibody is useful in understanding H3K27ac's role in transcriptional activation and enhancer elements and is widely used as a marker in studies of post-translational modifications, embryonic genome activation and developmental biology. This antibody is crucial in cancer research and is widely used in studies of histone modifications involving histone acetyltransferases (HATs) and histone deacetylases (HDACs).
文献引用 (2661)
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
NSD2抑制剂通过重塑染色质来治疗肺癌和胰腺癌。
Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer.
血管STING激活促进NK细胞在小细胞肺癌中的抗肿瘤免疫。
CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1.
通过 CRISPR 筛选人类胰腺癌异种移植瘤，发现 KLF5 增殖脆弱性与表观遗传修饰因子 NCAPD2 和 MTHFD1 有关。
CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.
CBFA2T2：一种新型的 H3K27 阅读器，可调节代谢和肿瘤生长。
State-specific enhancer landscapes govern microglial plasticity.
特定状态的增强子图谱控制着小胶质细胞的可塑性。
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei.
内质网锚定引导 TREX1 穿透微核处 BAF 依赖性屏障。
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.
H4K16 酰化作用会破坏染色质结构，并在代谢扰动期间促进转录反应。
Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5.
Af-CUT&Tag：一种灵敏且无需抗体的染色质分析方法，使用基因编码的标签和与 Tn5 融合的高亲和力结合剂。
Integrative functional genomics analysis identifies pleiotropic genes for vascular diseases.
整合功能基因组学分析鉴定出血管疾病的多效性基因。
Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.
顺式调控元件的鉴定有助于深入了解绵羊基因组中的组织特异性基因调控。
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