Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (Ab5103)

特异性

In peptide array this product recognises the Histone H3 (citrulline R2+R8+R17) peptide and shows minimal crossreactivity with the nonmodified peptide. Treatment is required for detection of the target protein. See Protocol section for detailed information. 更多详细信息请参阅 Protocol 部分.

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) is a rabbit polyclonal antibody and is validated for use in IP, PepArr and WB. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) was first used in a scientific publication in 2004 and has been cited over 595 times in peer reviewed journals. Abcam's high quality validation processes ensure Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has high sensitivity and specificity. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has 27 independent reviews from customers. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) specifically detects Histone H3 Citrulline-R2, Citrulline-R8, Citrulline-R17 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 100 µg selling sizes. Top cited antibody for this target with >800 citations. This antibody is a key tool in cancer research, particularly in understanding histone citrullination's role in tumorigenesis and is widely used in studies of gene expression, DNA repair and autoimmune diseases like rheumatoid arthritis and lupus, involving protein arginine deiminases (PADs) and NETosis. Histone hypercitrullination is reported to play a role the progression of various cancers, including multiple myeloma, acute myeloid leukaemia, lung cancer and hepatocellular carcinoma.