Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (Ab5131)
POLR2, POLR2A, DNA-directed RNA polymerase II subunit RPB1, RNA polymerase II subunit B1, 3'-5' exoribonuclease, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA-directed RNA polymerase II subunit RPB1, POLR2, POLR2A, DNA-directed RNA polymerase II subunit RPB1, RNA polymerase II subunit B1, 3'-5' exoribonuclease, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA-directed RNA polymerase II subunit RPB1
详细信息
特异性
This antibody recognises the phosphorylated serine found in the amino acid 5 position of the C-terminal domain repeat YSPTSPS of RNA polymerase II. From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.
背景信息
Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (ab5131) is a rabbit polyclonal antibody and is validated for use in ChIP, ELISA, ICC/IF, IHC - Wmt, IHC-Fr, IHC-P, IP, WB. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (ab5131) has been cited over 444 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (ab5131) has high sensitivity and specificity. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (ab5131) has 48 independent reviews from customers. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody (ab5131) specifically detects RNA polymerase II CTD repeat YSPTSPS Phospho-S5 (UniProt ID: P24928; Molecular weight: 217kDa) and is sold in 50 µg selling sizes. RNA polymerase II CTD repeat YSPTSPS (phospho S5) is crucial for transcription regulation and gene expression. Research indicates that phosphorylation at serine 5 is essential for the transition from transcription initiation to elongation, impacting various cellular processes and disease states. Phosphorylation of RNA polymerase II at serine 5 is critical for proper mRNA synthesis and processing. Abnormal phosphorylation patterns are linked to transcriptional dysregulation in cancer, pediatric gliomas, chondroblastomas, and neurodevelopmental syndromes. Studying these modifications can provide insights into potential therapeutic targets for various conditions. Phosphorylation of RNA polymerase II's largest subunit C-terminal domain (CTD) is a key event during mRNA metabolism.
文献引用 (428)
A single cluster of RNA Polymerase II molecules is stably associated with active genes.
单个RNA聚合酶II分子簇与活性基因稳定结合。
H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.
H3K4me1 指导陆生植物中 H3K36me2 和 H3K36me3 的沉积。
Transcription termination counteracts DNA damage after WEE1 inhibition.
转录终止可抵消 WEE1 抑制后的 DNA 损伤。
AATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism.
AATF 通过 NRF-1 依赖性机制维持线粒体呼吸，从而促进胶质母细胞瘤细胞的增殖。
Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans.
代谢基因HKDC1的沉默与小鼠和人类的衰老和神经退行性疾病有关。
Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation.
组蛋白乙酰转移酶 CBP 的催化依赖性和非催化依赖性功能促进先锋因子介导的合子基因组激活
Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts.
监测 NANOG 的快速降解表明 UTP15 通过调节新生转录本来维持多能性。
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α.
RNF20 通过 HIF1α 将 DNA 损伤反应和肺癌中的代谢重编程联系起来
Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants.
组蛋白 H3.3 中的单个氨基酸突变揭示了 H3K4 甲基化在植物中的功能意义
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