Anti-Iba1 antibody - Microglia marker (AB5076)

特异性

ab5076 is expected to recognize the isoforms represented by NP_001614 and NP_116573 but not NP_004838.

Find all reagents to label astrocytes in our Microglia markers guide. Anti-Iba1 antibody (ab5076) is a Goat Polyclonal antibody and is validated for use in IHC-P in human, rat samples. Anti-Iba1 antibody (ab5076) has been cited over 1354 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-Iba1 antibody (ab5076) has high sensitivity and specificity. Anti-Iba1 antibody (ab5076) has 100 independent reviews from customers. Anti-Iba1 antibody (ab5076) specifically detects Iba1 (UniProt ID: P55008; Molecular weight: 17kDa) and is sold in 100 ug selling sizes. Iba1 (Ionized calcium-binding adapter molecule 1; allograft inflammatory factor 1, AIF1) is a prominent microglial marker extensively used in neuroscience research. Its expression increases in various neurodegenerative conditions, including Alzheimer's disease (AD), indicating microglial activation and neuroinflammation. Researchers utilize Iba1 in stainings to assess microglial response and activity in different models, making it essential for understanding inflammatory processes in the brain. Changes in Iba1 expression provide valuable insights into neuroinflammation, highlighting its importance in studying diseases like AD. The Iba1 antibody (ab5076) is commonly used as a marker of microglia activation in staining and immunohistochemistry, given that ionized calcium binding adaptor molecule 1 (Iba1) is a microglia/macrophage-specific calcium-binding protein with actin-bundling activity that participates in membrane ruffling and phagocytosis in activated microglia.