Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (Ab5095)

RPB1, RPB220, SUA8, YDL140C, D2150, RPO21, DNA-directed RNA polymerase II subunit RPB1, RNA polymerase II subunit 1, RNA polymerase II subunit B1, DNA-directed RNA polymerase III largest subunit, RNA polymerase II subunit B220

反应种属:Human, Mouse, Rat, Yeast
抗原名称:RPO21 pS2
应用:WB, IHC, ELISA, IF/ICC

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Polyclonal
产品形式Liquid
纯化方式Affinity purification Immunogen
储存缓冲液pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
储存条件运输条件: Blue Ice 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help. This antibody recognises the phosphorylated serine found in the amino acid 2 position of the C-terminal domain repeat YSPTSPS.

背景信息

Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (ab5095) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC/IF, IHC-P, WB in human samples. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (ab5095) has been cited over 542 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (ab5095) has high sensitivity and specificity. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (ab5095) has 46 independent reviews from customers. Anti-RNA polymerase II CTD repeat YSPTSPS (phospho S2) antibody (ab5095) specifically detects RNA polymerase II CTD repeat YSPTSPS Phospho-S2 (UniProt ID: P04050; Molecular weight: 192kDa) and is sold in 100 µg selling sizes. RNA polymerase II CTD repeat YSPTSPS (phospho S2) plays a crucial role in transcription regulation and gene expression. This modification is essential for the proper functioning of RNA polymerase II, impacting various cellular processes. Antibodies targeting phospho S2 are valuable tools in research, particularly in studying diseases like cancer and neurodegenerative disorders. Understanding the phosphorylation of CTD repeat YSPTSPS can provide insights into the mechanisms underlying these diseases and aid in the development of targeted therapies.

文献引用 (593)

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm.

间期染色体构象是由通过有丝分裂染色体或细胞质遗传的不同折叠程序决定的。

Schooley Allana, Venev Sergey V, Aksenova Vasilisa, Lehman Jesse W, Navarrete Emily, Pai Athma A, Dasso Mary, Dekker Job

MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer.

MEN1 通过破坏 CD44 选择性剪接促进铁死亡,从而抑制肺癌。

Pan Ting, Zhu Jiamei, Wang Xuyan, Tang Dekun, Wang Ziming, Yang Yunqiao, Teng Yin, Tian Qianting, Dan Guixue, Chen Chaochun, Yu Dafang, Liu Mengyuan, Wang Houmei, Zhang Tuo, Guo Bing, Chen Tengxiang, Jin Bangming

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.

H3K4me1 指导陆生植物中 H3K36me2 和 H3K36me3 的沉积。

Wu Jiabing, Wang Jiachen, Du Kangxi, Li Yingping, Xie Wenhao, He Chenxi, Xing Qidan, Li Xiang, Zhu Xiaoyu, Wu Zhen, Wu Xiaolong, Zhang Linghao, Shen Wen-Hui, Lan Fei, Gan Jianhua, Liu Bing, Dong Aiwu

Hierarchical mechanisms control the clearance of DNA lesion-stalled RNA polymerase II.

层级机制控制着DNA损伤停滞的RNA聚合酶II的清除。

van der Meer Paula J, Yakoub George, Tsukada Kotaro, Nakazawa Yuka, Ogi Tomoo, Luijsterburg Martijn S

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity.

RAD51C-XRCC3 复合物调节 FANCM 介导的 R 环解析,以保障基因组完整性。

Inhibition of CDK9 sensitizes multidrug resistant ovarian cancer cells to paclitaxel.

抑制 CDK9 可使多药耐药卵巢癌细胞对紫杉醇敏感。

Wang Jinglu, Hornicek Francis J, Shi Huirong, Feng Wenlong, Duan Zhenfeng

RB dependent transcriptional regulation at mitotic centromeres preserves genome stability.

RB依赖的转录调控在有丝分裂着丝粒处维持基因组稳定性。

Crowley Elizabeth A, Manning Amity L

Topoisomerase I inhibition suppresses nuclear blebbing via RNA Pol II stalling and nuclear stiffening.

拓扑异构酶 I 抑制剂通过 RNA 聚合酶 II 停滞和核硬化来抑制核膜起泡。

Borowski Nickolas, Li Andy, Stephens Andrew D

Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium.

核膜深陷协调上皮细胞中染色质的空间组织。

Mäntylä Elina, Korpela Sanna, Rekonen Anna, Hakkola Sini, Karttunen Jenni, Pörsti Anni, Erämies Sanni, Tadeu Arrojo Martins Fábio, Davidsson Roselia, Ojanen Markus J T, Hakanen Satu A-M, Wang Peipei, Uusi-Mäkelä Joonas, Varlet Alice Anais, Vihinen-Ranta Maija, Conway Daniel E, Viiri Keijo, Nykter Matti, Lammerding Jan, Ihalainen Teemu O

Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedback.

全基因组DNA超螺旋是由转录和SMC活性引起的,并介导转录负反馈。

Zhu Linying, Yao Qian, Vemuri Charan, Chen Chongyi
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