详细信息
特异性
Recognizes ER membrane, mitochondria and cis-Golgi
背景信息
References regarding specificity Horner SM et al. Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci U S A 108:14590-5 (2011). PubMed: 21844353 Myhill N et al. The subcellular distribution of calnexin is mediated by PACS-2. Mol Biol Cell 19:2777-88 (2008). PubMed: 18417615 Yoshimura SI et al. Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus. J Cell Sci 114:4105-15 (2001). PubMed: 11739642 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (84)
Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion.
细胞外囊泡介导的 O-GlcNAcase 转移驱动神经元坏死，从而促进胆囊癌的神经周围侵袭。
Engineered CAR-T-Derived Exosomes Co-Delivering miR-145 and Cytotoxic Proteins for Targeted Solid Tumour Therapy.
工程化 CAR-T 衍生外泌体共递送 miR-145 和细胞毒性蛋白用于靶向实体瘤治疗。
Inhalation of mesenchymal stromal cell-derived extracellular vesicles activates macrophage polarization through the miR-22-3p/NLRP3/IL-1β pathway, ameliorating lung ischemia - reperfusion injury.
吸入间充质基质细胞衍生的细胞外囊泡可通过 miR-22-3p/NLRP3/IL-1β 通路激活巨噬细胞极化，从而改善肺缺血再灌注损伤。
Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis.
急性髓系白血病 (AML) 来源的骨髓间充质干细胞外泌体 METTL14 通过 HOXA3/WNT7B 轴促进 AML 细胞生长和糖酵解。
Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism.
自噬诱导的成骨细胞衍生的外泌体通过重塑肠道菌群代谢来维持骨形成并预防骨质疏松症。
Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting ABCB8 in Perioperative Neurocognitive Disorders After Prostate Surgery.
前列腺手术后围手术期神经认知障碍中，血浆来源的外泌体 hsa-miR-3677-3p 通过靶向 ABCB8 诱导神经元铁死亡。
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway.
细胞外囊泡通过 NRF2/AP-1 复合通路的前馈回路，将硫氧还蛋白输送到干细胞，从而挽救干细胞免于衰老和椎间盘退变
Microneedles combining delivery of hUMSC-derived exosomes and EGCG mitigate UV-induced skin damage
微针结合人脐带间充质干细胞来源的外泌体和表没食子儿茶素没食子酸酯（EGCG）的递送，可减轻紫外线引起的皮肤损伤。
Targeted neural stem cell-derived extracellular vesicles loaded with Sinomenine alleviate diabetic peripheral neuropathy via WNT5a/TRPV1 pathway modulation
靶向神经干细胞来源的胞外囊泡负载青藤碱可通过调节WNT5a/TRPV1通路缓解糖尿病周围神经病变。
Extracellular vesicles for delivery of functional telomerase.
用于递送功能性端粒酶的细胞外囊泡。
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