Anti-SQSTM1 / p62 antibody - Autophagosome Marker (Ab91526)
ORCA, OSIL, SQSTM1, Sequestosome-1, EBI3-associated protein of 60 kDa, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBIAP, p60, p62
详细信息
背景信息
Anti-SQSTM1 / p62 antibody (ab91526) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human samples. Anti-SQSTM1 / p62 antibody (ab91526) has been cited over 282 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-SQSTM1 / p62 antibody (ab91526) has high sensitivity and specificity. Anti-SQSTM1 / p62 antibody (ab91526) has 6 independent reviews from customers. Anti-SQSTM1 / p62 antibody (Anti-ORCA antibody) (ab91526) specifically detects SQSTM1 / p62 (UniProt ID: Q13501; Molecular weight: 48kDa) and is sold in 100 µg selling sizes. SQSTM1/p62 (Sequestosome 1) is a key protein involved in autophagy, serving as a bridge between ubiquitinated proteins and the autophagic machinery for their degradation. It is essential for maintaining cellular health and responding to stress. Abnormal p62 expression is associated with several diseases, including cancer, where it aids in tumor progression, and neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's disease (PD), where it is involved in the formation of protein aggregates.
文献引用 (306)
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
确定能够逆转具有朊病毒样结构域的 RNA 结合蛋白的有害相变的 RNA 寡核苷酸。
Biallelic GLTP mutations cause nonsyndromic epidermal differentiation disorder via disrupted epidermal glucosylceramide transport.
双等位基因 GLTP 突变通过破坏表皮葡糖基神经酰胺的转运，导致非综合征性表皮分化障碍。
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
靶向抑制 RGS19 可通过恢复自噬和调节免疫细胞浸润来缓解肾纤维化。
Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model.
Silmitasertib 是一种 FDA 指定的孤儿药 CK2 抑制剂，可改善亨廷顿病小鼠模型中的神经病理学和运动功能障碍。
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagy.
Bryostatin-1 可改善内皮细胞自噬受到抑制的动脉功能。
A Flupirtine Benzyl Carbamate Improves Neurocognitive Deficits and Molecular Pathology in the Cln6(nclf) Mouse.
氟吡汀苄基氨基甲酸酯可改善 Cln6(nclf) 小鼠的神经认知缺陷和分子病理。
Glutamine alleviates Staphylococcus aureus-induced mastitis by modulating macrophage polarisation.
谷氨酰胺通过调节巨噬细胞极化来缓解金黄色葡萄球菌引起的乳腺炎。
Recruitment of CCR5(+) inflammatory monocytes in pulmonary tissue contributes to acute lung injury.
肺组织中 CCR5(+) 炎症单核细胞的募集会导致急性肺损伤。
Heavy moxibustion at Sanyin point ameliorates neurogenic bladder dysfunction in spinal cord injury rats through the PI3â K/mTOR pathway.
在三阴穴进行重度艾灸可通过PI3K/mTOR通路改善脊髓损伤大鼠的神经源性膀胱功能障碍。
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.
多胺通过调节蛋白质稳态来维持老年肠道上皮细胞的再生。
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