Anti-CD68 antibody [KP1] (Ab955)

CD68, Macrosialin, Gp110

反应种属:Human
抗原名称:CD68
应用:WB, IHC, IF/ICC

用户验证的应用

推荐稀释比例

  • IHC-P1/3000 Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
  • WB1/1000
  • ICC/IF1/50

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Mouse / IgG1
抗体类型Monoclonal
全称Anti-CD68 antibody [KP1]
产品形式Liquid
储存缓冲液Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Blue Ice 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
纯化方式Affinity purification Protein A

背景信息

Anti-CD68 antibody [KP1] (ab955) is a mouse recombinant monoclonal antibody and is validated for use in ICC/IF, IHC-P and WB. Anti-CD68 antibody [KP1] (ab955) was first used in a scientific publication in 1989 and has been cited over 620 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in human and mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD68 antibody [KP1] (ab955) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD68 antibody [KP1] (ab955) has 44 independent reviews from customers. Anti-CD68 antibody [KP1] (ab955) specifically detects CD68 (UniProt ID: P34810; Molecular weight: 36kDa) and is sold in a convenient trial size to enable initial testing (10ug ) and larger sizes for subsequent scaling up experiments (100 ug and 1 mg). Conjugation-ready, carrier free format available for antibody clone KP1 - ab233172. Antibody clone KP1 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 555, Alexa Fluor ® 594, Alexa Fluor ® 647, Biotin ( ab222914, ab279323, ab282650, ab314474, ab317601 ). CD68 levels is implicated in autoimmune conditions like rheumatoid arthritis, where macrophages contribute to joint inflammation and damage. Specificity and sensitivity confirmed in IHC with multi-tissue microarray (TMA) validation What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (758)

Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia.

肿瘤-免疫-神经回路破坏癌症恶病质中的能量稳态。

Shi Xiuhui, Arreola Alex X, Zhou Zhijun, Yang Jingxuan, Liu Mingyang, Cai Yang, Ren Yu, Yuan Hao, Chen Qun, Chen Xinjie, Yang Xinyu, Meng Yimei, Wang Jingyi, Luo Wenyi, Rudolph Michael C, Varshney Rohan, Fung Kar-Ming, Xu Chao, Chen Wei R, Bronze Michael S, Zheng Lei, Li Yi-Ping, Houchen Courtney W, Zhang Yuqing, Li Min

Synergistic fusion of CD47, VE-cadherin and mussel adhesion protein promotes endothelialization and suppresses inflammation in vascular stents.

CD47、VE-钙黏蛋白和贻贝黏附蛋白的协同融合可促进血管支架内皮化并抑制炎症。

Yan Wenhua, Li Shuyu, Zhang Tian, Huang Junli, Deng Chengchen, Yuan Kunshan, Huang Nan, Zhang Haijun, Wang Guixue

Stromal vascular fraction self-assembles vascularized osteogenic organoids with immunomodulatory functions.

基质血管成分可自组装形成具有免疫调节功能的血管化成骨类器官。

Wu Jiazhou, He Ying, Qian Tao, Liu Zexian, Wu Yanbin, Li Yazhou, Jiang Hongyu, Ye Jianting, Lv Jia, Ma Biao, Luo Endong, You Jialiang, Wang Dingkai, Bai Yun, Zhang Junming, Zuo Liang, Peng Jiang

A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses.

利用冷冻保存的组织构建的肺部免疫双重人源化小鼠能够感染人类普通感冒冠状病毒并进行免疫分析。

Cheng Chunyu, Sun Jing, Lu Chun, Yu Qian, He Yiyun, Wu Bingqing, Ren Deshan, Ding Shuai, Zhao Jincun, Li Yan

Tertiary lymphoid structures correlate with reduced recurrence risk and enhanced antitumor immunity in esophageal squamous cell carcinoma with pathologic non-complete response to neoadjuvant chemoimmunotherapy.

对于接受新辅助化疗免疫疗法后病理反应不完全的食管鳞状细胞癌,三级淋巴结构与复发风险降低和抗肿瘤免疫增强相关。

Wo Yang, Lu Tong, Yang Zijiang, Li Xiongfei, Wang Zheyi, Peng Yizhou, Shen Xuxia, Hou Feng, Jiao Wenjie, Sun Yihua

Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis.

通过抑制 TNF/CELSR2/p65/Kla-HDAC1/EPAS1 轴,靶向间充质单核细胞衍生的巨噬细胞,以增强胶质母细胞瘤对替莫唑胺的敏感性。

Macrophage-to-myofibroblast transition (MMT) - An adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model.

巨噬细胞向肌成纤维细胞转变(MMT)——在非人灵长类动物模型中,对用于盆腔器官脱垂修复手术植入的聚丙烯网片的不良反应。

Therriault Marrisa A, Knight Katrina, Kottapalli Srividya, Obisesan Temitope, Harinath Malini, Brown Bryan N, Moalli Pamela A

A single-dose of PDGFB circular RNA enables sustained growth factor expression to accelerate diabetic wound healing.

单剂量 PDGFB 环状 RNA 可实现持续的生长因子表达,从而加速糖尿病伤口愈合。

Shen Yi-Qi, Zhang Yan, Yao Liu-Yi, Zhang Ru-Ke, Yang Bin, Deng Cheng-Cheng

Targeting AKR1B1 reprograms tumor-associated macrophages to enhance antitumor immunity.

靶向 AKR1B1 可重编程肿瘤相关巨噬细胞,从而增强抗肿瘤免疫力。

Liu Yuqing, Zhou Chao, Tang Yabin, Lei Huimin, Aihemaiti Ayinazhaer, Liu Hongyu, Zou Peichen, Xie Junting, Guo Xu, Xia Ruixue, Han Bao-Hui, Chen Hongzhuan, Zhu Liang

Dual regulation of CXCR6(+)CD8(+) T cells modulates cytotoxic and exhaustion-associated programs during prostate cancer progression.

CXCR6(+)CD8(+) T 细胞的双重调控在前列腺癌进展过程中调节细胞毒性和耗竭相关程序。

Xingming Zhang, Wang Jianhua, Abudurexiti Mierxiati, Du Leilei, Zhang Wei, Ni Xudong, Xu Midie, Zhang Xiaoyan, Zhang Min, Yao Zhu, Bian Xiaojie, Jin Shengming, Wang Wenfeng
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