Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (Ab108595)

LMN1, LMNA, Prelamin-A/C

反应种属:Human
抗原名称:LMNA
应用:WB, IHC, FCM, IF/ICC, IP

用户验证的应用

推荐稀释比例

  • IHC-P1/250 - 1/500 Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
  • WB1/10000 - 1/50000
  • ICC/IF1/250 - 1/500
  • Flow Cyt (Intra)1/100 - 1/150 ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • IP1/30

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Stable for 12 months at -20°C
纯化方式Affinity purification Protein A

背景信息

Product Specifications Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human samples. Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) specifically detects Lamin A + Lamin C (UniProt ID: P02545; Molecular weight: 74kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has been confirmed by testing in knockout samples. Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has been cited over 119 times in peer reviewed journals and is trusted by the scientific community. Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has 7 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR4100 - ab216074. Antibody clone EPR4100 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, PE, Alexa Fluor® 594, Alexa Fluor® 555, Alexa Fluor® 750, APC ( ab185014, ab193903, ab193904, ab210433, ab215324, ab320906, ab320907, ab320908 ). Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (151)

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双重靶向 AMRC12 和马拉色菌可破坏神经母细胞瘤中 MYC 液态凝聚物驱动的核孔复合体生物合成。

Phosphorylation-dependent modulation of the Lamin A/C-EZH2 complex regulates epithelial-mesenchymal plasticity.

Lamin A/C-EZH2 复合物的磷酸化依赖性调节调控上皮-间质可塑性。

Ak Balaji, Saha Santam, Sengupta Kundan

Evidence for Drop-Like Nuclear Deformation in Sheared Endothelial Monolayers.

剪切内皮单层细胞中液滴状核变形的证据。

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富含 IGF1 修饰 mRNA 的组织工程心脏贴片通过增强细胞存活和血管生成来缓解心肌梗死。

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细胞质 p21 通过激活 NF-κB 通路促进结肠癌细胞的干性。

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Serum response factor aggravates acute kidney injury via the NIK/NF-κB signaling in LPS-treated HK-2 cells.

血清反应因子通过 LPS 处理的 HK-2 细胞中的 NIK/NF-κB 信号通路加重急性肾损伤。

Pan Qun, Yu Qin, Luo Yanhong, Liao Yongli, Yang Ronghua

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties.

泡状体是具有细胞样特性的大型、富含细胞器的细胞外囊泡

Jeppesen Dennis K, Sanchez Zachary C, Kelley Noah M, Hayes James B, Ambroise Jessica, Koory Emma N, Krystofiak Evan, Taneja Nilay, Zhang Qin, Dungan Matthew M, Perkins Olivia L, Tyska Matthew J, Knapik Ela W, Dean Kevin M, Doran Amanda C, Coffey Robert J, Burnette Dylan T

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Zhen Wang # ,Ruofei Dai # ,Li Kang # ,Huan Yang # ,Zhaosu Chen ,Jianzhong He ,Lei Shu ,Yiting Zhong ,Yunfeng Zhang ,Zhengyi Hua ,Yuanyong Huang ,Yuhan Jiang ,Jiwen Li ,Liyan Xu ,Fei Lan ,Shu-Hai Lin ,Jiemin Wong
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