Anti-p21 antibody [EPR362] (Ab109520)
CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, CDKN1A, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, p21, MDA-6
详细信息
特异性
Expression levels of the target protein vary between different tissue/cell lines and in some cases induction may be required before a signal is observed.
背景信息
Anti-p21 antibody [EPR362] (ab109520) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP and WB. Anti-p21 antibody [EPR362] (ab109520) was first used in a scientific publication in 2014 and has been cited over 391 times in peer reviewed journals. It's performance in Western Blot in human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-p21 antibody [EPR362] (ab109520) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-p21 antibody [EPR362] (ab109520) has been confirmed by Western Blot testing in p21 knockout HeLa cells ( ab255349 ). Anti-p21 antibody [EPR362] (ab109520) has 13 independent reviews from customers. Anti-p21 antibody [EPR362] (ab109520) specifically detects p21 (UniProt ID: P38936; Molecular weight: 18kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR362 - ab218311. Antibody clone EPR362 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488 ( ab282187 ). p21 is a cyclin-dependent kinase inhibitor that regulates cell cycle progression, promoting cell cycle arrest in response to DNA damage. It plays a dual role in oncology by both suppressing tumor growth through cell cycle inhibition and contributing to cancer progression when localized in the cytoplasm. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (514)
Reversible ALKBH5 cytosolic aggregation accelerates cellular senescence.
ALKBH5胞质可逆聚集加速细胞衰老。
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.
靶向 KAT8 可通过调节 INHBA/TGF-β 通路缓解血管衰老。
Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma.
靶向衰老的 EGR1(+) B 细胞可增强食管鳞状细胞癌的免疫治疗效果。
Senolytic-loaded asymmetric wound dressing for targeted senescent cell clearance in diabetic wound healing.
用于糖尿病伤口愈合中靶向清除衰老细胞的载有衰老细胞清除剂的非对称伤口敷料。
Exosomal transfer of macrophage-derived NEAT1 enhances DNA damage response and confers cisplatin resistance in lung adenocarcinoma via the MAD1L1/p53 axis.
巨噬细胞来源的 NEAT1 外泌体转移通过 MAD1L1/p53 轴增强 DNA 损伤反应并赋予肺腺癌顺铂耐药性。
Lactate transmission from hypoxic tumor cells promotes macrophage senescence and M2 polarization via the DNMT1-NHE7 axis to accelerate endometrial cancer progression.
缺氧肿瘤细胞产生的乳酸通过 DNMT1-NHE7 轴促进巨噬细胞衰老和 M2 极化,从而加速子宫内膜癌的进展。
Isoliensinine inhibits mitophagy and sensitizes T cell malignancies for STING-mediated NK clearance.
异莲心碱抑制线粒体自噬,使 T 细胞恶性肿瘤对 STING 介导的 NK 清除更加敏感。
MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis.
MYLK4 通过靶向铁死亡来调节脂质代谢重编程,从而促进结直肠癌的进展。
Loss of ABCC6 in Human Mesenchymal Stem Cells Leads to Elevated Reactive Oxygen Species Formation and a Senescence-like Phenotype.
人类间充质干细胞中 ABCC6 的缺失会导致活性氧的形成增加和衰老样表型。
Morphofunctional State of the Liver Under Conditions of Three-Month Dark Deprivation: The Influence of Circadian Disruptions and Melatonin.
三个月黑暗剥夺条件下肝脏的形态功能状态:昼夜节律紊乱和褪黑激素的影响。
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