Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (Ab108986)

Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Ubiquitin thioesterase L1, PGP9.5, UCHL1

反应种属:Human, Mouse, Rat
抗原名称:UCHL1
应用:WB, IHC, FCM, IF/ICC, IP

用户验证的应用

推荐稀释比例

  • IHC-P1/250 - 1/1000 Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
  • WB1/1000 - 1/10000
  • ICC/IF1/500
  • Flow Cyt (Intra)1/100 - 1/10000 ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • IP1/10 - 1/100
  • IHC-Fr1/250 Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20)

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Stable for 12 months at -20°C
纯化方式Affinity purification Protein A

背景信息

Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (ab108986) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP and WB. Abcam's high quality manufacturing and validation processes ensure Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (ab108986) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (ab108986) has been confirmed by Western Blot testing in PGP9.5 knockout ab263773 cells ( ab263773 ). Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (ab108986) has 11 independent reviews from customers. Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (ab108986) specifically detects PGP9.5 (UniProt ID: P09936; Molecular weight: 25kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR4118 - ab220823. Antibody clone EPR4118 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 647, Alexa Fluor ® 555, Alexa Fluor ® 488, Alexa Fluor ® 594, Alexa Fluor ® 568, APC ( ab196173, ab300549, ab302578, ab302664, ab305109, ab317591 ). PGP9.5, also known as UCH-L1/UCHL1, is a crucial protein in neuro research, particularly for its role as a neuronal and neuroendocrine marker. It is widely used to stain neuronal cell bodies and axons in both the central and peripheral nervous systems. Researchers use PGP9.5 to assess nerve fiber density and integrity, making it essential for studying neurodegenerative diseases, small fiber neuropathy and various cancers. Its reliable expression in neurons helps in evaluating neuronal health and pathology in different neurological conditions. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (159)

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免疫相关性小纤维神经病变表现为疫苗相关SARS冠状病毒急性后综合征。

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天麻素通过抑制 NF-κB/NLRP3 通路介导的小胶质细胞炎症来缓解硼替佐米引起的周围神经病变。

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巨噬细胞可保护周围神经免受感觉轴突损伤

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