Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (Ab109012)
ORCA, OSIL, SQSTM1, Sequestosome-1, EBI3-associated protein of 60 kDa, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBIAP, p60, p62
用户验证的应用
推荐稀释比例
- WB1/10000 - 1/50000
- ICC/IF1 µg/mL
- Flow Cyt (Intra)1/10 - 1/100 ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
详细信息
背景信息
Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IP and WB. Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) was first used in a scientific publication in 2014 and has been cited over 445 times in peer reviewed journals. It's performance in Western Blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) has been confirmed by Western Blot testing in SQSTM1 / p62 knockout HEK-293T cells ( ab263770 ). Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) has 15 independent reviews from customers. Anti-SQSTM1 / p62 antibody [EPR4844] - Autophagosome Marker (ab109012) specifically detects SQSTM1 / p62 (UniProt ID: Q13501; Molecular weight: 48kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR4844 - ab219581. Antibody clone EPR4844 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, HRP, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 555, APC, PE ( ab185015, ab194720, ab194721, ab203429, ab203430, ab225093, ab225094 ). NEW: Explore our alternative host species for clone [EPR4844]: goat. SQSTM1, also known as p62, is a multifunctional scaffolding protein widely used in neuro research for its role in autophagy and protein degradation. It is upregulated in several neurodegenerative disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Researchers use SQSTM1/p62 to study the mechanisms of protein aggregation and neuroinflammation, making it essential for understanding the progression of neurodegenerative diseases and identifying potential therapeutic targets. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (835)
Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation.
谷氨酰胺分解过度通过精氨酸-mTORC1轴激活驱动衰老。
GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy.
在眼咽远端肌病中,新的开放阅读框内的 GGC 重复扩增被翻译成有毒的聚甘氨酸蛋白。
ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease.
ESRRA-ATG5介导的线粒体自噬增强精氨酸代谢,从而缓解糖尿病肾病。
Autophagy regulates the maternal-to-zygotic transition through MAP1LC3B-mediated maternal mRNA decay.
自噬通过 MAP1LC3B 介导的母源 mRNA 降解来调节母源向合子转变。
TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1.
TP53BP2 通过 G9a 和 DNMT1 协同调节 E2F1 促进胎盘自噬和先兆子痫。
MCUB Inhibits PRKN-Dependent Mitophagic Degradation of PD-L1 to Promote Immune Evasion in Bladder Cancer.
MCUB抑制PRKN依赖的PD-L1线粒体自噬降解,从而促进膀胱癌的免疫逃逸。
Distinct neuronal alterations distinguish two subtypes of sporadic Creutzfeldt-Jakob disease with shared dysfunctional pathways.
散发性克雅氏病的两个亚型具有不同的神经元改变,但它们都存在共同的功能障碍通路。
Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer's disease.
重塑肠道菌群:杜仲皮多糖缓解阿尔茨海默病学习和记忆障碍的新观点。
Sex-specific acceleration of Alzheimer's pathogenesis by chronic sleep-deprivation.
慢性睡眠剥夺会加速阿尔茨海默病的发病进程,且这种加速作用具有性别特异性。
Tripartite motif 13 orchestrates endoplasmic reticulum-associated degradation and endoplasmic reticulum-phagy to modulate dendritic cell-mediated immune responses in sepsis.
三方基序 13 协调内质网相关降解和内质网吞噬,从而调节脓毒症中树突状细胞介导的免疫反应。
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