Anti-p21 antibody [EPR3993] (Ab109199)

CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1, CDKN1A, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, p21, MDA-6

反应种属:Human, Mouse, Rat
抗原名称:CDKN1A
应用:WB

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Stable for 12 months at -20°C
无载体蛋白No

特异性

Expression levels of the target protein vary between different tissue/cell lines and in some cases, induction may be required before a signal is observed. This antibody is not recommended for use in WB with tissue and primary cell samples. We recommended ab109520 and ab188224 for use in IHC.

背景信息

Product Specifications Anti-p21 antibody [EPR3993] (ab109199) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in WB in human, mouse, rat samples. Anti-p21 antibody [EPR3993] (ab109199) specifically detects p21 (UniProt ID: P38936; Molecular weight: 18kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-p21 antibody [EPR3993] (ab109199) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-p21 antibody [EPR3993] (ab109199) has been confirmed by testing in knockout samples. Anti-p21 antibody [EPR3993] (ab109199) has been cited over 305 times in peer reviewed journals and is trusted by the scientific community. Anti-p21 antibody [EPR3993] (ab109199) has 10 independent reviews from customers. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (357)

SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration.

SOD1 乳酸化通过构象变化损害其酶活性,从而加剧椎间盘退变。

Zhang Yuyao, Zhai Yu, Liu Chao, Chen Minghang, Zhang Yang, Bian Zhiqun, Chang Xian, Hu Zhilei, Li Jianmin, Zhang Chao, Ni Zhenhong, Xie Yangli, Chen Lin, Liu Minghan, Li Changqing

Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation.

环境中的环丙沙星引发流产:通过 TRIM21 介导的 MFF 降解导致衰老驱动的流产。

Sun 孙义 Yi, Lin 林晏冰 Yanbing, Xing å¹¸å¸ å¸ Shuaishuai, Huang 黄文欣 Wenxin, Wang Yanxin, Guo Geng, Yan Haijun, Zhao Depeng, Cheng Wenli, Wu Zhengzhong, Huang Chenghui, Zhang Zhihong, Wu 吴琳琳 Linlin, Hou 侯青芝 Qingzhi, Zhang å¼ æ §ä¸œ Huidong

HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription.

HK2 驱动的组蛋白 H3K18 乳酸化通过 CUX1 介导的 SASP 因子转录促进 URSA 中的基质细胞衰老和蜕膜化缺陷。

Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis.

环状RNA circPLXNC1通过调节自噬在骨关节炎中发挥抑制衰老的作用。

Zhou Hongyi, Ji Zhongyin, Sun Heng, Zhang Wanda, Huang Yizhen, Jin Gu, Cai Haoyu, Huang Xu'an, Dai Jiafeng, Zhao Junduo, Chen Haojie, Fan Shunwu, Wu Yizheng, Shen Jianxiong

MYLK4 promotes colorectal cancer progression by regulating lipid metabolism reprogramming via targeting ferroptosis.

MYLK4 通过靶向铁死亡来调节脂质代谢重编程,从而促进结直肠癌的进展。

METTL3-mediated m6A modification regulates CDKN1A to attenuate chronic sleep deprivation-induced cognitive impairment and neuronal apoptosis in rats

METTL3介导的m6A修饰调节CDKN1A,从而减轻慢性睡眠剥夺引起的大鼠认知障碍和神经元凋亡

Fei Xing #,Xiao-Shan Shi #,Han-Wen Gu,Pan-Miao Liu,Lei Lei,Min Jia,Xing-Ming Wang,Mu-Huo Ji,Jian-Jun Yang

Alterations in mitochondria and cellular senescence in aged sEH null female kidneys.

老年 sEH 基因敲除雌性肾脏中线粒体和细胞衰老的改变。

Yousef Ala, Fang Liye, Heidari Mobina, Huang Andy, Kondraciuk Patrick, Yee Kristen A, Mengel Michael, Seubert John M

Dasatinib and quercetin mitigate radiation-induced lung injury by eliminating senescent cells in a rat model.

达沙替尼和槲皮素通过消除大鼠模型中的衰老细胞来减轻辐射引起的肺损伤。

Liu Jing, Ren Xue, Wang Hengjiao, Yang Defu, Yan Ying, Xu Ying

Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle.

老年人骨骼肌在肢体固定后一周内会出现大量的免疫细胞浸润和巨噬细胞衰老。

Skiles Chad M, Fennel Zachary J, Bourrant Paul-Emile, Yee Elena M, Castro Robert J, Zabriskie Hannah A, Itinose Melina, Supiano Mark A, O'Connell Ryan M, Drummond Micah J

S100A14 Facilitates Pancreatic Cancer Progression via S100A16-Mediated p53 Suppression.

S100A14 通过 S100A16 介导的 p53 抑制促进胰腺癌进展。

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