MFN2 Polyclonal antibody (12186-1-AP)
CPRP1; EC:3.6.5.-; HSG; KIAA0214; MARF
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | mouse brain tissue, HeLa cells, mouse kidney tissue, rat brain tissue, rat heart tissue, mouse liver tissue, rat kidney tissue, rat liver tissue |
| Positive IP detected in | mouse kidney tissue |
| Positive IHC detected in | human colon cancer tissue, mouse kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MFN2, also named as CPRP1 and KIAA0214, belongs to the mitofusin family. It is an Essential transmembrane GTPase, which mediates mitochondrial fusion. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression of MFN2 induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6). Ubiquitinated forms of Mfn2 (mono- and polyubiquitinated) are present during mitophagy.
文献引用 (176)
Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction.
脑缺血性中风后纤维化瘢痕形成：靶向 Sonic hedgehog 信号通路以减少瘢痕
Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy
设计的缺氧反应性白蛋白纳米粒子介导线粒体自噬调节用于癌症治疗
Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy.
鼠伤寒沙门氏菌通过其效应因子 SseJ 诱导的 PHB2 介导的线粒体自噬持续感染宿主
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
可注射的 pH 响应导电水凝胶，用于智能递送二甲双胍和外泌体，以增强心肌缺血再灌注损伤后的心脏修复
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
ARMC1 在不同的复合物之间分配，并与 MTFR 组装 MIRO 以控制线粒体分布
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
钙稳态失衡会干扰 AMPK/Drp1 通路，从而破坏线粒体稳态，加剧斑块进展和不稳定性。
USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2.
USP10 通过稳定细胞质 Mfn2 来防止压力超负荷引起的线粒体形态功能缺陷和病理性心脏肥大
Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity
发现一种新型查尔酮衍生的共价Keap1结合剂，可减轻顺铂引起的线粒体功能障碍和肾毒性
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
二甲双胍通过激活 Ethe1/Keap1/PINK1 通路缓解多囊卵巢综合征的肝脏代谢功能障碍
Impact of POU3F4 mutation on cochlear development and auditory function
POU3F4 突变对耳蜗发育和听觉功能的影响
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