用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | Jurkat cells, L02 cells, mouse kidney tissue, NIH/3T3 cells, Raji cells, Ramos cells, mouse lung tissue, rat lung tissue, C6 cells |
| Positive IP detected in | mouse kidney tissue |
| Positive IHC detected in | human liver tissue, human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
GCLC (Glutamate--cysteine ligase catalytic subunit) belongs to the glutamate--cysteine ligase type 3 family. It is also known as GLCL and GLCLC. It is the first rate-limiting enzyme in glutathione (GSH) biosynthesis. GCLC may be associated with coronary endothelial vasomotor dysfunction and myocardial infarction (MI) (PMID:12598062). Defects in GCLC are the cause of hemolytic anemia (HAGGSD).
文献引用 (50)
Identification of CD84 as a potent survival factor in acute myeloid leukemia
鉴定 CD84 为急性髓系白血病中的一种强效生存因子
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice.
肝脏特异性 Bcl3 敲除通过激活 Nrf2 通路减轻对乙酰氨基酚引起的雄性小鼠肝损伤
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
空气污染会降低小鼠大脑皮层突触体中的突触后 PSD-95 和 NMDA 受体亚基
Baicalin attenuated metabolic dysfunction-associated fatty liver disease by suppressing oxidative stress and inflammation via the p62-Keap1-Nrf2 signalling pathway in db/db mice.
黄芩苷通过抑制 db/db 小鼠体内 p62-Keap1-Nrf2 信号通路中的氧化应激和炎症，减轻了代谢功能障碍相关的脂肪肝疾病
The gut microbiota-mediated ferroptosis pathway: a key mechanism of ginsenoside Rd against metabolism-associated fatty liver disease.
肠道菌群介导的铁死亡途径：人参皂苷 Rd 对抗代谢相关脂肪肝疾病的关键机制
Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism.
褪黑素通过刺激内质网应激和抑制丙氨酸-丝氨酸-半胱氨酸转运蛋白 2 驱动的谷氨酰胺代谢，诱导胰腺癌细胞发生铁死亡
Langqing Meiduo Jiujie pills treatment attenuates acute liver injury in animals by regulating anti-oxidative stress and liver metabolism.
狼毒美多止痛丸通过调节抗氧化应激和肝脏代谢来减轻动物的急性肝损伤
Glutamate-cysteine ligase as a diagnostic biomarker and therapeutic target in Parkinson's disease: a multi-omics and experimental study.
谷氨酸-半胱氨酸连接酶作为帕金森病诊断生物标志物和治疗靶点：一项多组学和实验研究
SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress.
SMND-309 激活 Nrf2 信号通路，以减轻对乙酰氨基酚引起的肝毒性和氧化应激
Carnosic acid attenuates diabetic retinopathy via the SIRT1 signaling pathway: neuroprotection and endothelial cell preservation.
鼠尾草酸通过 SIRT1 信号通路减轻糖尿病视网膜病变：神经保护和内皮细胞保护
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