用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | RAW 264.7 cells, MC38 cells, RT-4 cells, mouse adipose tissue, mouse skeletal muscle tissue, rat heart tissue, human adipose tissue, rat adipose tissue |
| Positive IHC detected in | mouse skin tissue, human heart tissue, human ovary tumor tissue, rat brown adipose tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | A431 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Fatty acid binding protein (FABP) 4 is a member of the FABP family which abundantly expressed, fatty acid carrier proteins. FABPs are capable of binding a variety of hydrophobic molecules such as long-chain fatty acids and are important for their uptake and intracellular trafficking. It was first identified as an adipocyte-specific protein, important for the maintenance of lipid and glucose metabolism. It is also detected in macrophages, where it participates in regulating inflammation and cholesterol trafficking via NFκB and PPAR. In more recent studies, FABP4 has been found in a variety of endothelial cells, where it has been identified as a target of VEGF and a regulator of cell proliferation and possibly angiogenesis. Pathologically, FABP4 has been associated with the development of metabolic syndrome, diabetes and cancer and vulnerability of atherosclerotic plaques. FABP4 has been identified as a novel prognostic factor for both adverse cardiovascular events and breast cancer.
文献引用 (46)
Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear
揭示PIEZO1在肩袖撕裂后肌肉脂肪浸润中纤维生成/脂肪生成祖细胞脂肪生成中的作用
A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA
一种新的人类特异性 lncRNA MEK6-AS1 通过稳定 MEK6 mRNA 来调节脂肪生成和脂肪酸生物合成
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue.
异甘草素通过激活棕色脂肪组织来改善高脂饮食诱导的小鼠肥胖
Epac1 Inhibits Orbital Fibroblast Activation to Ameliorate Thyroid-Associated Orbitopathy-Like Features Through the JAK/STAT Signaling Pathway.
Epac1 通过 JAK/STAT 信号通路抑制眼眶成纤维细胞活化，从而改善甲状腺相关眼病样特征
Ursolic acid suppresses triple-negative breast cancer progression through mediating FABP4/PPARG pathway
熊果酸通过调节FABP4/PPARG通路抑制三阴性乳腺癌的进展。
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling
限时喂养通过重塑肠道菌群调节肝脏烟酰胺代谢，改善非酒精性脂肪肝
Exosomal miR-1a-3p derived from glucocorticoid-stimulated M1 macrophages promotes the adipogenic differentiation of BMSCs in glucocorticoid-associated osteonecrosis of the femoral head by targeting Cebpz
糖皮质激素刺激的 M1 巨噬细胞来源的外泌体 miR-1a-3p 通过靶向 Cebpz 促进糖皮质激素相关股骨头坏死中 BMSCs 的脂肪形成分化
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4
肠道微生物产生的乙酸通过 FABP4 延缓中性粒细胞凋亡，从而促进脓毒症引起的急性呼吸窘迫综合征
EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling
EEF1B2 通过 Wnt/β-catenin 信号调节骨髓间充质干细胞骨脂平衡
Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1
人参皂苷 Rb1 影响线粒体 Ca2+ 转运，通过调节 wnt 信号通路抑制脂肪沉积和纤维化，通过与 SFRP1 对接治疗肩袖撕裂
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