SNAI1 Polyclonal antibody (13099-1-AP)
SLUGH 2; SLUGH2; SNAI 1; SNAIL1; Zinc finger protein SNAI1
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | mouse heart tissue, PC-3 cells, BxPC-3 cells, human heart tissue, COLO 320 cells, MCF-7 cells |
| Positive IP detected in | MCF-7 cells |
| Positive IHC detected in | human stomach cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
SNAI1, a member of SNAI1 family of protein, participates in the epithelial to mesenchymal transition(EMT) and formation and maintenance of embryonic mesoderm. The snail family share a common structural, that a highly conserved C-terminal region containing a zinc finger transcription factor. SNAI1 interacts with other corepressor, such as Ajuba, PRMT5 and SIN3a or HDAC1 and 2, to repress the target gene. As the phosphorylation modification of SNAI1 protein, the range of molecular weight of SNAI1 is about 25-30 kDa (PMID: 22276203 ). Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
文献引用 (204)
DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma.
DSS1抑制自噬，从而激活肾细胞癌促转移微环境中的上皮-间质转化
Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression
脂肪细胞特异性Zeb1下调重塑肿瘤相关脂肪微环境，促进女性乳腺癌进展。
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
顺铂新辅助化疗通过 MMP14 介导的 EMT 激活上调 GSDMD，从而增强口腔鳞状细胞癌的转移
Targeting the self-amplifying loop between ATF6 and SNAI1 to inhibit epithelialâmesenchymal transition in fibrotic lesions.
靶向 ATF6 和 SNAI1 之间的自我放大环路，以抑制纤维化病变中的上皮-间质转化
Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway
人脂肪干细胞外泌体通过miR-199a-3p靶向Twist1并调控TGFβ1/Smad3通路，抑制上皮-间质转化，从而减轻放射线对唾液腺的损伤。
Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy.
含有si-Cx43纳米颗粒和抗VEGF剂的热敏水凝胶复合材料，用于协同治疗糖尿病视网膜病变
eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.
eNAMPT/Ac-STAT3/DIRAS2 轴通过增强肿瘤相关巨噬细胞与癌细胞之间的细胞因子串扰来促进三阴性乳腺癌的发展和癌症干性
ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1.
ATG7 缺陷的成纤维细胞通过外泌体介导的 SCARB1 下调促进乳腺癌进展
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
SIRT5介导的PPA2去琥珀酰化增强了HIF-1α依赖的对缺氧应激的适应和结直肠癌转移
Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2
Smad2 与 TGIF2 协同作用，通过共同靶向 SOX2 促进胰腺癌的 EMT 和癌症干细胞特性
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