MFN1 Polyclonal antibody (13798-1-AP)
Mitofusin-1; mitofusin 1; hfzo2; hfzo1; Fzo homolog
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HSC-T6 cells, T-47D cells, mouse brain tissue, mouse kidney tissue, mouse liver tissue |
| Positive IP detected in | mouse kidney tissue |
| Positive IHC detected in | human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HEK-293 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Mitofusin-1 (MFN1) is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). Mitofusins are large predicted GTPases located in the outer mitochondrial membrane. They are essential for outer membrane fusion by interacting with each other to facilitate mitochondrial targeting. The mitofusins are the first known protein mediator of mitochondrial fusion, and mediate developmentally regulated post-meiotic fusion of mitochondria.Mfn1 is required on adjacent mitochondria to mediate fusion via interactions of a heptad repeat region that mediates oligomerization of the protein(PMID:16892085). Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy(PMID: 20871098).
文献引用 (138)
Dual regulation of mitochondrial fusion by Parkin-PINK1 and OMA1.
Parkin-PINK1 和 OMA1 对线粒体融合的双重调控
PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover
PNPLA6 通过磷脂周转，利用胆碱调节视网膜稳态。
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
IDO1 在肺纤维化中的关键作用：从肺成纤维细胞线粒体融合和靶向分子抑制的角度
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
ARMC1 在不同的复合物之间分配，并与 MTFR 组装 MIRO 以控制线粒体分布
USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2.
USP10 通过稳定细胞质 Mfn2 来防止压力超负荷引起的线粒体形态功能缺陷和病理性心脏肥大
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer
靶向过度表达的叶酸受体的放射性可裂解稀土纳米激活剂可诱导线粒体功能障碍并重塑胰腺癌中的免疫抑制微环境
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
紫草酸蚀刻的 ZIF-8 纳米颗粒通过抑制炎症信号通路和修复线粒体损伤来延缓骨关节炎的进展
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
通过药物靶向线粒体磷酸酶 PTPMT1 可使肝细胞癌对铁死亡敏感
Impact of POU3F4 mutation on cochlear development and auditory function
POU3F4 突变对耳蜗发育和听觉功能的影响
A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1.
Parkin 的底物相互作用区指导线粒体 GTP 酶 Miro1 的泛素化
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