p38 MAPK Polyclonal antibody (14064-1-AP)
MAPK14; CSAID-binding protein; CSBP; CSBP1; CSBP2
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, Jurkat cells, mouse heart tissue, RAW 264.7 cells, NIH/3T3 cells, rat spleen tissue, Neuro-2a cells, rat heart tissue, K-562 cells |
| Positive IHC detected in | human colon cancer tissue, human liver cancer tissue, mouse heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T(H)17 differentiation and inflammation(PMID:22231518). It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell(PMID:21198398). This protein has some isoforms with MW 29-31 kDa, 35 kDa and 41 kDa.
文献引用 (142)
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
4-辛基衣康酸酯通过激活ERK信号促进血管生成，从而减轻心肌缺血再灌注损伤
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes.
H3K18 乳酸化介导的核苷酸结合寡聚化结构域 2 (NOD2) 表达促进胆红素诱导的星形胶质细胞焦亡
Febrile temperature-regulated TRPV1 in CD4(+) T cells mediates neuroinflammation in complex febrile seizures.
CD4(+) T 细胞中的发热温度调节 TRPV1 介导复杂性热性惊厥中的神经炎症
Targeting HPK1 inhibits neutrophil responses to mitigate post-stroke lung and cerebral injuries
靶向HPK1可抑制中性粒细胞反应，从而减轻卒中后肺部和脑损伤。
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
PINK1 调节 Prdx2 以减少脂毒性诱导的细胞凋亡，并减轻射血分数保留的心力衰竭小鼠的心脏功能障碍
Luteolin 7-Glucuronide in Artemisia rupestris L. Extract Attenuates Pulmonary Fibrosis by Inhibiting Fibroblast Activation and FMT via Targeting of TGF-β1.
蒿属植物提取物中的木犀草素 7-葡糖醛酸苷通过靶向 TGF-β1 抑制成纤维细胞活化和 FMT 来减轻肺纤维化
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
增强胰腺癌治疗：H101溶瘤病毒在不可逆电穿孔中的作用
Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury.
小胶质细胞中 Per2 缺乏可通过抑制脊髓损伤中的铁死亡来缓解运动功能障碍
ADCY5 Gene Affects Seasonal Reproduction in Dairy Goats by Regulating Ovarian Granulosa Cells Steroid Hormone Synthesis.
ADCY5 基因通过调节卵巢颗粒细胞类固醇激素合成影响奶山羊的季节性繁殖
Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer.
槐定通过靶向乳腺癌细胞中的 PIM1 来抑制其增殖和迁移
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