用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, L02 cells, MCF-7 cells, MDA-MB-231 cells |
| Positive IP detected in | L02 cells |
| Positive IHC detected in | human kidney tissue, human skeletal muscle tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
SREBF1, also named as BHLHD1 and SREBP1, contains one basic helix-loop-helix (bHLH) domain and belongs to the SREBP family. It is a transcriptional activator required for lipid homeostasis. The SREBPs are synthesized as precursors anchored to endoplasmic reticulum (ER) membranes and complexed with SCAP. When the cellular cholesterol level is low, SREBP-SCAP complexes move to the Golgi apparatus, where SREBPs undergo a two-step proteolytic processing, leading to the release of the mature form, an N-terminal fragment, i.e, basic helix-loop-helix leucine zipper transcription factor. These factors enter the nucleus where they bind to sterol regulatory elements (SRE) in the promoter regions of a number of genes whose products mediate the synthesis of cholesterol and fatty acids. [PMID: 21698267]. This antibody can recognize the 125 kDa precursor form and the 68 kDa mature form of human SREBF1.
文献引用 (94)
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
辛伐他汀可克服 AKT 过度激活的肝内胆管癌中 pPCK1-pLDHA-SPRINGlac 轴介导的铁死亡和化疗免疫疗法耐药性
Helicobacter hepaticus promotes hepatic steatosis through CdtB-induced mitochondrial stress and lipid metabolism reprogramming
肝螺杆菌通过CdtB诱导的线粒体应激和脂质代谢重编程促进肝脂肪变性
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes.
海豹（Phocaeicola vulgatus）在对糖尿病患者二甲双胍疗效产生负面影响方面起着关键作用
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
利什曼原虫肽通过调节脂肪酸合成代谢抑制类风湿性关节炎中异常活化的成纤维细胞样滑膜细胞
N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury.
N-乳酰苯丙氨酸通过 AMPK-PGC1α-PPARα 通路调节小胶质细胞/巨噬细胞的脂质代谢，从而促进脊髓损伤小鼠的恢复
Anthraquinones of Cassiae Semen alleviate lipid accumulation in obesity by regulating brown adipose tissue and liver function.
决明子中的蒽醌类化合物通过调节棕色脂肪组织和肝脏功能来缓解肥胖中的脂质积累
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma
Lipin1依赖的SREBP转录失活导致多发性骨髓瘤对selinexor敏感
DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway
DLAT 通过 JAK2/STAT5A/SREBP1 信号通路调节脂质代谢，参与卵巢癌进展
Rno-miR-130b Attenuates Lipid Accumulation Through Promoting Apoptosis and Inhibiting Differentiation in Rat Intramuscular Adipocytes.
Rno-miR-130b 通过促进大鼠肌内脂肪细胞凋亡和抑制其分化来减轻脂质积累
Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell.
鉴定新型 58-5p 和 SREBF1 相互作用及其对绵羊卵巢颗粒细胞凋亡的影响
- 1
- 2
- 3
- 4
- 5
- 6
- 10