用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, NCI-H1299 cells, SH-SY5Y cells, Neuro-2a cells, C6 cells, mouse brain tissue, rat brain tissue |
| Positive IP detected in | A549 cells |
| Positive IHC detected in | mouse brain tissue, human intrahepatic cholangiocarcinoma tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
| Positive IF-Fro detected in | mouse brain tissue |
| Positive IF/ICC detected in | A549 cells, mouse brain tissue |
| Positive FC (Intra) detected in | C6 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
UCHL1(Ubiquitin carboxyl-terminal hydrolase isozyme L1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons(PMID: 6343558). This protein is present in brain at concentrations at least 50 times greater than in other organs and is a major protein component of neuronal cytoplasm (PMID:7217993). And UCHL1 is a Parkinson's disease susceptibility gene (PMID:15048890).
文献引用 (67)
Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages
气道基底干细胞对于维持功能性上皮内气道巨噬细胞是必需的。
Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth
神经密度增加会对结直肠癌的结果产生不利影响，而神经支配则会抑制肿瘤的生长
Carnosol, a Rosemary Ingredient Discovered in a Screen for Inhibitors of SARM1-NAD(+) Cleavage Activity, Ameliorates Symptoms of Peripheral Neuropathy.
迷迭香中的一种成分——鼠尾草酚，是在筛选 SARM1-NAD(+) 裂解活性抑制剂时发现的，它能改善周围神经病变的症状
Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy
NGFR100W 和 VEGFA mRNA 共递送可增强糖尿病周围神经病变中的血管和神经修复
Deficiency of Aging-Related Gene Chitinase-Like 4 Impairs Olfactory Epithelium Homeostasis.
衰老相关基因几丁质酶样 4 的缺乏会损害嗅觉上皮稳态
Dietary Fatty Acid Composition Alters Gut Microbiome in Mice with Obesity-Induced Peripheral Neuropathy
膳食脂肪酸组成改变肥胖诱发周围神经病变小鼠的肠道微生物群
Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae
Spiner，一种基于深度学习的完整耳蜗中螺旋神经节神经元自动检测方法
Quiescent horizontal basal stem cells act as a niche for olfactory neurogenesis in a mouse 3D organoid model
在小鼠三维类器官模型中，静止的水平基底干细胞可作为嗅觉神经发生的微环境。
Mechanisms of Neuronal Differentiation and Notch Signaling as a Potential Therapeutic Target in Olfactory Dysfunction of Allergic Rhinitis.
神经元分化机制和 Notch 信号传导作为过敏性鼻炎嗅觉功能障碍的潜在治疗靶点
Schwann Cell Protein Kinase RNA-like ER Kinase (PERK) Is Not Necessary for the Development of Diabetic Peripheral Neuropathy but Negates the Efficacy of Cemdomespib Therapy.
雪旺细胞蛋白激酶 RNA 样内质网激酶 (PERK) 不是糖尿病周围神经病变发展所必需的，但会抵消 Cemdomespib 疗法的疗效
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