Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (Ab8580)

H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, H3C1, HIST1H3C, H3FC, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H3K4me3, H3K4me, H3K4

反应种属:Human, Bovine
抗原名称:H3C1 tri methyl K4
应用:WB, IHC, IF/ICC, ChIP, Peptide Array

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Polyclonal
产品形式Liquid
纯化方式Affinity purification Immunogen
储存缓冲液pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
储存条件运输条件: Blue Ice 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle

背景信息

Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) is a rabbit polyclonal antibody and is validated for use in ChIP, ICC/IF, IHC-P, PepArr and WB. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) was first used in a scientific publication in 2002 and has been cited over 2135 times in peer reviewed journals. It's performance in ChIP in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) has high sensitivity and specificity. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) has 92 independent reviews from customers. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) specifically detects Histone H3 Tri Methyl-K4 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 50 µg selling sizes. Top cited antibody for this target with >2000 citations and >60 five star abreviews. Trimethylation of histone H3 (H3K4me3) is a key epigenetic mark that consistently occurs at transcription start sites, promoting higher transcription activity. H3K4me3 is considered a marker and used as a control for gene activation. It plays a crucial role in cell identity during pre-implantation development and in deriving embryonic stem cells from the inner cell mass and trophoblast stem cells from the trophectoderm. Histone H3 lysine 4 trimethylation (H3K4me3) plays a significant role in cancer by regulating gene expression and chromatin structure.

文献引用 (2041)

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm.

间期染色体构象是由通过有丝分裂染色体或细胞质遗传的不同折叠程序决定的。

Schooley Allana, Venev Sergey V, Aksenova Vasilisa, Lehman Jesse W, Navarrete Emily, Pai Athma A, Dasso Mary, Dekker Job

Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N(6)-methyladenosine recognition protein YTHDC2.

利用深度学习辅助发现一种强效且具有细胞活性的 RNA N(6)-甲基腺苷识别蛋白 YTHDC2 抑制剂。

Yang Zhenyu, Sun Weining, Huang Qiao, Li Yueyue, Yuan Meng, Yang Yu, Zhao Heng, Liu Zheyi, Zeng Xiaoxi, Wang Fangjun, Jiang Yuanyuan, Zhao Yi, Chen Runsheng

Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.

顺式调控元件的鉴定有助于深入了解绵羊基因组中的组织特异性基因调控。

Xie Shangqian, Davenport Kimberly M, Salavati Mazdak, Caulton Alex, Clark Emily L, Archibald Alan L, Clarke Shannon M, Brauning Rudiger, Massa Alisha T, Mousel Michelle R, White Stephen N, Worley Kim C, Murdoch Gordon K, Becker Gabrielle, Stegmiller Morgan R, Khilji Sarem F, Shira Katie A, Olagunju Temitayo A, Hadfield Tracy, McKay Stephanie D, Rosen Benjamin D, Cockett Noelle E, Smith Timothy P L, Murdoch Brenda M

Mechanisms of gene regulation by SRCAP and H2A.Z.

SRCAP 和 H2A.Z 的基因调控机制

Tollenaere Armelle, Ugur Enes, Dalla Longa Susanna, Deluz Cédric, Assenheimer Devin, Gebhardt J Christof M, Leonhardt Heinrich, Suter David M

Mutation in HER1 enhances stigma exsertion and hybrid seed production in rice.

HER1基因突变可增强水稻柱头伸出和杂交种子生产。

Guo Daiming, Du Kangxi, Xu Peizhou, Liu Su, Li Mengyuan, Dong Jiazhi, Zhao Jingcheng, Zhang Mingming, Zhou Gege, Li Yong, Yuan Xinmiao, Jin Fangli, Zhao Zhixue, Yu Shicong, Xia Duo, Zhang Hongyu, Chen Xiaoqiong, Luo Ming, Ali Asif, Tian Yunfeng, Zhou Hao, Wu Xianjun, Liao Yongxiang

Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.

对共存染色质特征的 DNA 甲基化和羟甲基化进行测序。

Araujo Tavares Rafael de Cesaris, Dhir Somdutta, He Xuan, Monahan Jack, Taipale Minna, Golder Paula, Ciau-Uitz Aldo, Gosal Walraj, Tannahill David, Balasubramanian Shankar

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory.

SET结构域蛋白和HCF-1维持跨代表观遗传记忆。

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses.

海马雌激素水平、受体类型和表观遗传学导致性别特异性记忆对同时发生的急性应激的脆弱性。

Hokenson Rachael E, Rodríguez-Acevedo Kiara L, Chen Yuncai, Short Annabel K, Samrari Sara A, Devireddy Brinda, Jensen Brittany J, Winter Julia J, Gall Christine M, Soma Kiran K, Heller Elizabeth A, Baram Tallie Z

Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

自噬及时调控PHGDH介导的丝氨酸代谢,以支持卵母细胞发育。

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL-HIF2α-Controlled Adipocyte Function.

VHL-HIF2α控制的脂肪细胞功能对造血稳态和骨形成进行分叉调节。

Li Qian, Li Jia, Tang Anshu, Li Cong, Zhang Chao, Zhang Congcong, Liu Yun-Cai
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