CD44 Polyclonal antibody (15675-1-AP)
CD44 antigen; CDW44; CSPG8; ECMR III; ECMR-III
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, HeLa cells, HUVEC cells, MDA-MB-231 cells |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | human lung cancer tissue, human colon cancer tissue, human oesophagus cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human colon cancer tissue |
| Positive IF/ICC detected in | HeLa cells, human colon cancer tissue, A375 cells, HUVEC cells, UCMSCs cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CD44 is a type I transmembrane glycoprotein that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands. Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. This protein exists in multiple forms (with molecular weight ranging from 16 kDa to over 200 kDa) generated by alternative RNA splicing and extensive post-translational modifications.
文献引用 (142)
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
可注射的 ECM 模拟动态水凝胶通过递送髓核祖细胞衍生的外泌体来消除铁死亡诱导的椎间盘切除术后疝。
Neurotransmitter-Mimicking Nanovesicles Facilitate Postoperative Glioblastoma Stem Cell-Specific Treatment for Preventing Tumor Recurrence.
模拟神经递质的纳米囊泡促进术后胶质母细胞瘤干细胞特异性治疗，以预防肿瘤复发
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.
双靶向生物脂质体纳米药物修复内皮细胞功能障碍并恢复巨噬细胞胆固醇流动稳态，以治疗早期动脉粥样硬化
Single-cell multi-omics analysis identifies SPP1(+) macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy.
单细胞多组学分析发现 SPP1(+) 巨噬细胞是黄韧带肥大中铁死亡介导的纤维化的关键驱动因素
Stepwise targeting hyaluronic acid-based polymeric prodrug for acute kidney injury and prevents its progression to chronic kidney disease.
逐步靶向透明质酸基聚合物前药治疗急性肾损伤，并防止其发展为慢性肾病
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
衰老成纤维细胞分泌 CTHRC1 以促进肝细胞癌的干性
Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2
Smad2 与 TGIF2 协同作用，通过共同靶向 SOX2 促进胰腺癌的 EMT 和癌症干细胞特性
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
与 CasL-2 相互作用的分子可促进肿瘤进展并改变宫颈癌的放射敏感性
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction
ITIH5 介导的成纤维细胞/巨噬细胞串扰加剧心肌梗死后的心脏重塑
TNFâα induces premature senescence in tendon stem cells via the NFâκB and p53/p21/cyclin E/CDK2 signaling pathways.
TNF-α通过NF-αB和p53/p21/cyclin E/CDK2信号通路诱导肌腱干细胞过早衰老
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