Anti-NLRP3 antibody [EPR23094-1] (Ab263899)
C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1
详细信息
特异性
NLRP3 is related with inflammation and is cell-type dependent. This antibody detects no signal or very weak signal in most non-diseased tissue samples and untreated cell lysates. Stimulation may be required to allow detection of the NLRP3 protein in most samples, as described in the literature (PMID: 29070054, 29434227, and 22569257). FURTHER INFORMATION ON SPECIFICITY (Chinese Version) available under the product protocols section. This file includes key technical notes of experience when using this product.
背景信息
Anti-NLRP3 antibody [EPR23094-1] (ab263899) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), I-ELISA, IP and WB. Anti-NLRP3 antibody [EPR23094-1] (ab263899) was first used in a scientific publication in 2020 and has been cited over 253 times in peer reviewed journals. It's performance in Western blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-NLRP3 antibody [EPR23094-1] (ab263899) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-NLRP3 antibody [EPR23094-1] (ab263899) has been confirmed by Western Blot testing in NLRP3 knockout THP-1 cells ( ab280063 ). Anti-NLRP3 antibody [EPR23094-1] (ab263899) specifically detects NLRP3 (UniProt ID: Q96P20; Molecular weight: 119kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR23094-1 - ab264468. NLRP3 inflammasome plays a crucial role in immunology and disease by regulating innate immune responses. It contributes to the development of various immune and inflammation-related diseases, including arthritis, Alzheimer's disease and inflammatory bowel disease. EPR23094-1 is one of the top cited clones on the market with over 527 citations Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (647)
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
黑素细胞中 NLRP3 自噬降解紊乱是导致白癜风发生的原因之一。
Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury.
在缺血性脑损伤小鼠模型中，半乳糖凝集素-3介导单核细胞衍生巨噬细胞内的溶酶体相关炎症。
Resveratrolâloaded selfâassembled tetrahedral framework nucleic acids reshape the epileptic microenvironment by regulating oxidative stress and neuroinflammation via the SIRT3/SOD2 pathway.
白藜芦醇负载的自组装四面体框架核酸通过 SIRT3/SOD2 通路调节氧化应激和神经炎症，从而重塑癫痫微环境。
The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosis.
G9a-TRIM21 轴通过诱导 FoxO3a 的甲基化依赖性泛素化和降解，促进氧化应激和细胞焦亡，从而加剧糖尿病肾脏缺血再灌注损伤。
Ultrasmall Cu(2-x)Se nanoparticles alleviate vascular calcification through inhibiting oxidative stress and NF-κB/NLRP3-mediated inflammation.
超小 Cu(2-x)Se 纳米颗粒通过抑制氧化应激和 NF-κB/NLRP3 介导的炎症来缓解血管钙化。
Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice.
Cry2 缺陷通过微生物群-肠-脑轴介导的 S1P/NLRP3/IL-1β 通路导致小鼠认知障碍。
Multifunctional nanofibrous membranes enhance diabetic wound healing by inhibiting endothelial pyroptosis and regulating macrophage polarization.
多功能纳米纤维膜通过抑制内皮细胞焦亡和调节巨噬细胞极化来促进糖尿病伤口愈合。
Bionic Nanoparticle Hydrogel for Astrocyte-Targeted Estradiol Delivery Ameliorates Perimenopausal Depression via P2X7 Receptor Inhibition.
仿生纳米颗粒水凝胶靶向星形胶质细胞递送雌二醇，通过抑制 P2X7 受体改善围绝经期抑郁症。
Tripartite motif 13 orchestrates endoplasmic reticulum-associated degradation and endoplasmic reticulum-phagy to modulate dendritic cell-mediated immune responses in sepsis.
三方基序 13 协调内质网相关降解和内质网吞噬，从而调节脓毒症中树突状细胞介导的免疫反应。
An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson's disease.
靶向 NLRP3 的自主 siRNA 递送系统：对帕金森病的影响。
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