Beta Tubulin Polyclonal antibody (10094-1-AP)
Tubulin beta 3 chain; Tubulin beta III; β III tubulin; βIII tubulin; TUBB4
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | U-251 cells, mouse kidney tissue, HEK-293 cells, rat kidney tissue, mouse brain tissue, rat brain tissue |
| Positive IP detected in | mouse brain tissue |
| Positive IHC detected in | human colon tissue, human cerebellum tissue, mouse brain tissue, rat testis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse eye tissue |
| Positive IF/ICC detected in | HeLa cells, HepG2 cells |
| Positive FC (Intra) detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
There are five tubulins in human cells: alpha, beta, gamma, delta, and epsilon. Tubulins are conserved across species. They form heterodimers, which multimerize to form a microtubule filament. An alpha and beta tubulin heterodimer is the basic structural unit of microtubules. The heterodimer does not come apart, once formed. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha, beta, and gamma tubulins have all been used as loading controls. Tubulin expression may vary according to resistance to antimicrobial and antimitotic drugs.
文献引用 (349)
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation.
帕金森病双通路靶向治疗：仿生纳米体通过 NLRP3 炎症小体调节抑制铁死亡和细胞焦亡
Targeting phagocytosis for amyloid-β clearance: implications of morphology remodeling and microglia activation probed by bifunctional chimaeras.
靶向吞噬作用清除淀粉样蛋白β：双功能嵌合体探究形态重塑和小胶质细胞活化的意义
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
自噬通过 SQSTM1/p62 介导的选择性自噬来调节细胞衰老，从而介导 CDKN1A/p21 和 CDKN2A/p16 的降解，进而导致粘液瘤样二尖瓣退化
Integrative Multi-Omics Approaches Reveal Selectivity Profiles and Molecular Mechanisms of FIIN-2, a Covalent FGFR Inhibitor.
整合多组学方法揭示了共价 FGFR 抑制剂 FIIN-2 的选择性特征和分子机制
PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway.
PHGDH 激活通过丝氨酸合成途径促进胶质母细胞瘤的进展和放射抗性
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity.
圣草酚-顺铂包覆纳米药物协同促进骨肉瘤细胞铁死亡和化疗敏感性
Lacc1-engineered extracellular vesicles reprogram mitochondrial metabolism to alleviate inflammation and cartilage degeneration in TMJ osteoarthritis.
Lacc1 工程化的细胞外囊泡重编程线粒体代谢，以减轻颞下颌关节骨关节炎的炎症和软骨退化
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
VIRMA 介导的 m(6)A 修饰通过调节核糖体生物合成来调控前脑的形成
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