CDK2 Polyclonal antibody (10122-1-AP)
CDKN2; Cell division protein kinase 2; Cyclin dependent kinase 2; Cyclin-dependent kinase 2; EC:2.7.11.22
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HepG2 cells, MCF-7 cells, A431 cells, NIH/3T3 cells, rat kidney tissue, HEK-293 cells, Hela cells, Jurkat cells, K-562 cells |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | mouse testis tissue, human prostate cancer tissue, human liver cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse testis tissue |
| Positive IF/ICC detected in | HepG2 cells |
| Positive FC (Intra) detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CDK2(Cyclin-dependent kinase 2) is also named as CDKN2 and belongs to the protein kinase superfamily,CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily.It is involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis.It has 2 isoforms produced by alternative splicing.
文献引用 (112)
The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth.
LINC01315 编码的小蛋白 YAPer-ORF 与 PRP4k 竞争，劫持 YAP 信号传导，从而异常地促进细胞生长
Integrative Transcriptome-Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility.
整合转录组范围关联研究与表达数量性状基因座共定位鉴定出鼻咽癌易感性的致病 VAMP8 变异
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.
利用靶向细胞周期调控实现非侵入性椎间盘再生的声电微环境
BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma
BET抑制剂与BCG疫苗联合使用可增强抗肿瘤疗效并调控T细胞重编程以治疗黑色素瘤。
MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity.
MTCH2 调节 NRF2 介导的 RRM1 表达，从而促进黑色素瘤增殖和达卡巴嗪不敏感性
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma
双重 HDAC/PI3K 抑制剂 CUDC-907 可抑制 MYC 驱动的 3 组髓母细胞瘤的生长和增殖。
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation
CircSMAD3 通过促进 hnRNPA1 泛素化降解来抑制 VSMC 表型转换和新内膜形成
Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levels.
人参皂苷 Rg5 通过转录和翻译后水平调节细胞周期蛋白，增强 ER+ 乳腺癌对阿贝西利的敏感性
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
益母草碱通过 Hippo-YAP 通路减轻 CCl(4) 诱导的小鼠肝纤维化
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
IGF2BP3 招募 NUDT21 来调节 SPTBN1 的选择性多聚腺苷酸化，从而驱动卵巢癌的进展
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