ATG5 Polyclonal antibody (10181-2-AP)
APG5; APG5 LIKE; APG5L; APG5-like; Apoptosis specific protein
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, HeLa cells, mouse kidney tissue, HepG2 cells |
| Positive IP detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ATG5, also named as APG5L and ASP, belongs to the ATG5 family. It is required for autophagy. It plays an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. It mediates autophagosome-independent host protection. This antibody is raised against 28-275 amino acids of human ATG5. It can recognize the ATG5-ATG12 complex (55 kDa) which can be truncated and generate a 40-45 kDa band. 10181-2-AP also recognizes the free ATG5 (32 kDa).
文献引用 (125)
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
USP19 通过去泛素化 NEK9 抑制 mTOR 通路，从而增强胰腺癌细胞的自噬性细胞死亡
E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.
E2F1-自噬-ALDH1A1轴以p53依赖的方式增强肺癌干细胞样细胞的自我更新和耐药性
ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy.
ATP6AP1 通过诱导自噬促进管腔型乳腺癌细胞增殖和三苯氧胺耐药性
Pharmacological targeting of the mitochondrial phosphatase PTPMT1 sensitizes hepatocellular carcinoma to ferroptosis.
通过药物靶向线粒体磷酸酶 PTPMT1 可使肝细胞癌对铁死亡敏感
The p97 ATPase and its adaptor UBXD8 maintain peroxisome pools by preventing pexophagy.
p97 ATPase 及其衔接蛋白 UBXD8 通过阻止过氧化物酶体自噬来维持过氧化物酶体池
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
IGF2BP1-HAX-1 正反馈环介导的 HAX-1 过表达阻断自噬通量，促进鼻咽癌的化疗耐药性
Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms.
猪 cGAS-STING 信号诱导的细胞凋亡通过不同的机制负向调节 STING 下游 IFN 反应和自噬
Targeting p38γ synergistically enhances sorafenib-induced cytotoxicity in hepatocellular carcinoma
靶向 p38γ 可协同增强索拉非尼诱导的肝细胞癌细胞毒性
Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis
靶向心肌细胞中的 NLRC5 可通过增强 CAVIN1/CAV1 轴的自噬通量来保护梗塞后心脏损伤
Apigenin attenuates the atherosclerotic lesions through enhancing selective autophagy/lipophagy and promoting RCT process.
芹菜素通过增强选择性自噬/脂质自噬和促进 RCT 过程来减轻动脉粥样硬化病变
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