用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293 cells, HEK-293T cells, HeLa cells, SH-SY5Y cells, Neuro-2 cells, mouse brain tissue, mouse liver tissue, rat brain tissue, rat liver tissue, Jurkat cells, human placenta tissue |
| Positive IP detected in | HEK-293 cells, HeLa cells |
| Positive IHC detected in | human liver cancer tissue, human colon tissue, human heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
| Positive IF/ICC detected in | HEK-293 cells, HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
The enzymatic function of Cu/Zn Superoxide Dismutase (SOD1), previously known as hemocuprein and IPOA, was first characterized in 1969 (PMID: 5389100). SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription. In disease contexts, SOD1 is best-known for its role in a familial form of amyotrophic lateral sclerosis (fALS) (PMID: 10630188). In addition, SOD1 is overexpressed in numerous cancer types, including lung adenocarcinoma, non-small-cell lung cancer , and 70% of primary breast cancers (PMID: 31344643).
文献引用 (99)
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
植物化学纳米酶可重编程氧化还原状态，从而在急性和慢性糖尿病伤口中实现平衡的抗菌和再生治疗
Hyaluronidase-responsive hydrogel loaded with magnetic nanoparticles combined with external magnetic stimulation for spinal cord injury repair.
载有磁性纳米粒子的透明质酸酶响应水凝胶结合外部磁刺激用于脊髓损伤修复
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
方奇诺林通过调节牛磺酸代谢和氧化应激来减轻肝纤维化
Supplementing Freezing Medium with Crocin Exerts a Protective Effect on Bovine Spermatozoa Through the Modulation of a Heat Shock-Mediated Apoptotic Pathway.
在冷冻培养基中添加藏红花素可通过调节热休克介导的细胞凋亡途径对牛精子发挥保护作用
Exogenous H(2)S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis.
外源性 H(2)S 通过 USP22/SIRT1 轴降低 HepG2 细胞中脂质混合物引起的氧化应激
Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients.
希腊石榴籽油对 N2a 神经母细胞瘤细胞和轻度认知障碍患者的神经保护、抗氧化和抗炎作用
Vascular Smooth Muscle-Secreted Exosomal X26nt Impedes Atherosclerosis Progression via the c-FOS/XBP1/SOD1 Axis
血管平滑肌分泌的外泌体X26nt通过c-FOS/XBP1/SOD1轴抑制动脉粥样硬化进展
Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats
异甜菊醇钠促进大鼠脊髓损伤模型的神经功能恢复
Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling.
大豆皂苷 Bb 通过挽救 GSK-3β/Nrf2 信号传导来减轻雄性小鼠吗啡戒断引起的焦虑样行为
Extracellular Mitochondrial-Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction
细胞外线粒体衍生的囊泡通过调节氧化应激和线粒体功能障碍影响糖尿病足部溃疡的进展
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